Annals of Surgical Oncology

, Volume 24, Issue 4, pp 1037–1045

Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma

  • Shinya Okumura
  • Toshimi Kaido
  • Yuhei Hamaguchi
  • Atsushi Kobayashi
  • Hisaya Shirai
  • Yasuhiro Fujimoto
  • Taku Iida
  • Shintaro Yagi
  • Kojiro Taura
  • Etsuro Hatano
  • Hideaki Okajima
  • Shinji Uemoto
Hepatobiliary Tumors

DOI: 10.1245/s10434-016-5668-3

Cite this article as:
Okumura, S., Kaido, T., Hamaguchi, Y. et al. Ann Surg Oncol (2017) 24: 1037. doi:10.1245/s10434-016-5668-3

Abstract

Background

Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC).

Methods

A retrospective analysis was performed of 109 patients undergoing resections of ICC between January 2004 and April 2015. Skeletal muscle mass [skeletal muscle index (SMI)], skeletal muscle quality [muscle attenuation (MA)], and visceral adiposity [visceral to subcutaneous adipose tissue area ratio (VSR)] were measured on preoperative computed tomography images. The impacts of these parameters on outcomes after ICC resections were analyzed.

Results

The overall survival rates were significantly lower in patients with low SMI (P = 0.002), low MA (P = 0.032), and high VSR (P = 0.026) compared with patients with high SMI, high MA, and low VSR, respectively. With multivariate analyses, in patients with stage I–III, low SMI (hazard ratio (HR) 3.29, P = 0.003) and low MA (HR 2.86, P = 0.010) were revealed as independent significant risk factors for mortality. In patients with stage IV, none of these parameters was identified as risk factors, with only the absence of adjuvant chemotherapy identified as an independent risk factor for mortality (HR 5.92, P = 0.001).

Conclusions

Although stage was the most important factor, low skeletal muscle mass and quality were closely related to mortality after resection of ICC in patients with stage I–III.

Abbreviations

AUC

Area under the curve

BMI

Body mass index

CI

Confidence interval

CRP

C-reactive protein

CT

Computed tomography

HCC

Hepatocellular carcinoma

HR

Hazard ratio

HU

Hounsfield Unit

ICC

Intrahepatic cholangiocarcinoma

LT

Liver transplantation

MA

Muscle attenuation

OS

Overall survival

RFS

Recurrence-free survival

ROC

Receiver operating characteristic

SMI

Skeletal muscle index

TNM

Tumor node metastasis

UICC

Union for International Cancer Control

VSR

Visceral to subcutaneous adipose tissue area ratio

Supplementary material

10434_2016_5668_MOESM1_ESM.docx (98 kb)
Supplementary material 1 (DOCX 97 kb)

Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Shinya Okumura
    • 1
  • Toshimi Kaido
    • 1
  • Yuhei Hamaguchi
    • 1
  • Atsushi Kobayashi
    • 1
  • Hisaya Shirai
    • 1
  • Yasuhiro Fujimoto
    • 1
  • Taku Iida
    • 1
  • Shintaro Yagi
    • 1
  • Kojiro Taura
    • 1
  • Etsuro Hatano
    • 1
  • Hideaki Okajima
    • 1
  • Shinji Uemoto
    • 1
  1. 1.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of MedicineKyoto UniversityKyotoJapan

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