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Annals of Surgical Oncology

, Volume 24, Issue 2, pp 494–501 | Cite as

Ultrasonically Activated Shears Reduce Blood Loss without Increasing Inflammatory Reactions in Open Distal Gastrectomy for Cancer: A Randomized Controlled Study

  • Seung-Young Oh
  • Boram Choi
  • Kyung-Goo Lee
  • Hwi-Nyeong Choe
  • Hye-Joo Lee
  • Yun-Suhk Suh
  • Seong-Ho Kong
  • Hyuk-Joon Lee
  • Woo Ho Kim
  • Han-Kwang Yang
Gastrointestinal Oncology

Abstract

Background

Previous studies regarding ultrasonically activated shears (UAS) were performed without controlled surgical procedures or consideration of potential thermal injury due to high temperature of active blade of UAS. The purpose of this study was to evaluate the efficacy and safety of UAS through a comparison with conventional monopolar electrocautery (CME) in open distal gastrectomy for gastric cancer.

Methods

From October 2011 to November 2012, 56 gastric cancer patients eligible for open distal gastrectomy were randomized into UAS or CME groups. Primary endpoints were estimated blood loss (EBL) during surgery and amount of drainage through the fifth postoperative day. Secondary endpoints were operation time, length of hospital stay, postoperative morbidity, changes in cytokine levels in serum, peritoneal irrigation saline, and peritoneal drainage, and inflammatory markers of serum. (Registration-number of ClinicalTrials.gov: NCT01971775).

Results

EBL was lower in the UAS group than that in the CME group (339.8 ± 201.2 vs. 428.6 ± 165.8 mL, p = 0.021). However, the amount of postoperative drainage was not significantly different between the two groups. Although the complication rate was not different between the two groups, there were three cases of intra-abdominal bleeding requiring transfusion only in the CME group. Inflammatory markers from the cytokine assays and serum laboratory tests showed no significant differences between the two groups.

Conclusions

UAS reduced EBL without increasing inflammatory reactions.

Keywords

Gastric Cancer Estimate Blood Loss Distal Gastrectomy Cytology Examination Cytokine Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosure

This study was an investigator-initiated trial supported by a research grant from Johnson & Johnson Medical Korea.

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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Seung-Young Oh
    • 1
  • Boram Choi
    • 2
  • Kyung-Goo Lee
    • 1
  • Hwi-Nyeong Choe
    • 3
  • Hye-Joo Lee
    • 3
  • Yun-Suhk Suh
    • 1
  • Seong-Ho Kong
    • 1
  • Hyuk-Joon Lee
    • 1
    • 2
  • Woo Ho Kim
    • 2
    • 4
  • Han-Kwang Yang
    • 1
    • 2
  1. 1.Department of SurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Cancer Research InstituteSeoul National University College of MedicineSeoulKorea
  3. 3.Department of NursingSeoul National University HospitalSeoulKorea
  4. 4.Department of PathologySeoul National University College of MedicineSeoulKorea

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