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Annals of Surgical Oncology

, Volume 23, Supplement 5, pp 746–754 | Cite as

CD151 Gene and Protein Expression Provides Independent Prognostic Information for Patients with Adenocarcinoma of the Esophagus and Gastroesophageal Junction Treated by Esophagectomy

  • Oliver M. Fisher
  • Angelique J. Levert-Mignon
  • Christopher W. Lehane
  • Natalia K. Botelho
  • Jesper L. V. Maag
  • Melissa L. Thomas
  • Melanie Edwards
  • Sarah J. Lord
  • Yuri V. Bobryshev
  • David C. Whiteman
  • Reginald V. LordEmail author
Gastrointestinal Oncology

Abstract

Background

Esophageal and gastroesophageal junctional (GEJ) adenocarcinoma is one of the most fatal cancers and has the fastest rising incidence rate of all cancers. Identification of biomarkers is needed to tailor treatments to each patient’s tumor biology and prognosis.

Methods

Gene expression profiling was performed in a test cohort of 80 chemoradiotherapy (CRTx)-naïve patients with external validation in a separate cohort of 62 CRTx-naïve patients and 169 patients with advanced-stage disease treated with CRTx.

Results

As a novel prognostic biomarker after external validation, CD151 showed promise. Patients exhibiting high levels of CD151 (≥median) had a longer median overall survival than patients with low CD151 tumor levels (median not reached vs. 30.9 months; p = 0.01). This effect persisted in a multivariable Cox-regression model with adjustment for tumor stage [adjusted hazard ratio (aHR), 0.33; 95 % confidence interval (CI), 0.14–0.78; p = 0.01] and was further corroborated through immunohistochemical analysis (aHR, 0.22; 95 % CI, 0.08–0.59; p = 0.003). This effect was not found in the separate cohort of CRTx-exposed patients.

Conclusion

Tumoral expression levels of CD151 may provide independent prognostic information not gained by conventional staging of patients with esophageal and GEJ adenocarcinoma treated by esophagectomy alone.

Keywords

Gene Expression Omnibus Validation Cohort Multimodality Therapy Resection Margin Status CD151 Protein Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Oliver M. Fisher is supported by the Australian National Health & Medical Research Council (NHMRC; GNT1094423) and the Swiss National Science Foundation (P1SKP3_161806). David C. Whiteman is supported by a Research Fellowship (APP1058522) from the NHMRC. The Australian Cancer Study was supported by NHMRC Program Grants (#552429). PROBENET was supported by an NHMRC Centre of Research Excellence Grant (APP1040947) and this study was supported in part by Darryl and Ann Courtney O’Connor through the Curran Foundation of St. Vincent’s Hospital.

Disclosure

None to declare.

Supplementary material

10434_2016_5504_MOESM1_ESM.docx (34.9 mb)
Supplementary material 1 (DOCX 35730 kb)

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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Oliver M. Fisher
    • 1
    • 2
    • 6
  • Angelique J. Levert-Mignon
    • 1
  • Christopher W. Lehane
    • 1
  • Natalia K. Botelho
    • 1
  • Jesper L. V. Maag
    • 2
    • 3
  • Melissa L. Thomas
    • 1
  • Melanie Edwards
    • 4
  • Sarah J. Lord
    • 1
    • 5
    • 6
  • Yuri V. Bobryshev
    • 1
  • David C. Whiteman
    • 7
  • Reginald V. Lord
    • 1
    • 6
    Email author
  1. 1.Gastroesophageal Cancer ProgramSt. Vincent’s Centre for Applied Medical ResearchSydneyAustralia
  2. 2.School of Medical SciencesUNSW AustraliaSydneyAustralia
  3. 3.Genomics & Epigenetics DivisionGarvan Institute of Medical ResearchSydneyAustralia
  4. 4.Douglass Hanley Moir PathologySydneyAustralia
  5. 5.NHMRC Clinical Trials CentreUniversity of SydneySydneyAustralia
  6. 6.Department of Surgery, School of MedicineUniversity of Notre DameSydneyAustralia
  7. 7.QIMR Berghofer Medical Research InstituteBrisbaneAustralia

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