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Annals of Surgical Oncology

, Volume 23, Issue 12, pp 3860–3869 | Cite as

Locoregional Recurrence Risk for Postmastectomy Breast Cancer Patients With T1–2 and One to Three Positive Lymph Nodes Receiving Modern Systemic Treatment Without Radiotherapy

  • Shih-Fan Lai
  • Yu-Hsuan Chen
  • Wen-Hung Kuo
  • Huang-Chun Lien
  • Ming-Yang Wang
  • Yen-Shen Lu
  • Chiao Lo
  • Sung-Hsin KuoEmail author
  • Ann-Lii Cheng
  • Chiun-Sheng HuangEmail author
Breast Oncology

Abstract

Background

Administering postmastectomy radiotherapy (PMRT) to patients with T1–2 breast cancer and one to three positive axillary lymph nodes (ALNs) is controversial. The current study assessed the association of clinicopathologic features and molecular subclassification with locoregional recurrence (LRR) in patients who did not receive PMRT.

Methods

Between January 2004 and December 2008, 293 patients with T1–2 breast cancer and one to three positive ALNs not receiving PMRT were analyzed. Most of the patients received an anthracycline- or taxane-based regimen or both. The patients were divided according to the four molecular subtypes as follows: luminal A/B, luminal human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative breast cancer. Overall survival (OS) and LRR were calculated using the Kaplan–Meier method, and the clinicopathologic prognostic factors were compared using log-rank tests and the Cox regression model.

Results

After a median follow-up period of 82.8 months, the 10-year LRR and OS were respectively 10 %, and 88.9 %. The patients with triple-negative breast cancer had a higher 5-year LRR rate (10.6 %) than those without this disease (4.2 %) (p = 0.05). Multivariate analysis showed that young age (≤40 years), tumor larger than 3 cm, and the presence of extensive intraductal components were significant risk factors for LRR. The 5-year LRR was 3.1 % for the patients without the aforementioned risk factors, 7.9 % for those with one risk factor, and 25 % for those with two or more risk factors (p < 0.001).

Conclusions

Administering modern systemic therapy to early breast cancer patients not receiving PMRT reduced the LRR rate. Younger patients, those with a tumor larger than 3 cm, and those with extensive intraductal components might benefit from PMRT.

Keywords

Axillary Lymph Node Dissection Sentinel Lymph Node Dissection Extensive Intraductal Component Aforementioned Risk Factor Positive ALNs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The authors thank the Cancer Registry, Cancer Administration and Coordination Center, National Taiwan University Hospital for providing the necessary patient information. This study was supported by research Grants MOST 104-2314-B-002-189-MY3, 104-2811-B-002-058, and 104-2314-B-002-152-MY3 from the Ministry of Science and Technology, Taiwan, and Grants MOHW104-TD-B-111-04 and MOHW105-TDU-B-211-134005 from the Ministry of Health and Welfare, Taiwan.

Compliance with Ethical Standards

Conflict of Interest

There are no conflicts of interest.

Supplementary material

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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Shih-Fan Lai
    • 1
    • 2
  • Yu-Hsuan Chen
    • 2
  • Wen-Hung Kuo
    • 3
  • Huang-Chun Lien
    • 4
  • Ming-Yang Wang
    • 3
  • Yen-Shen Lu
    • 2
    • 5
  • Chiao Lo
    • 3
  • Sung-Hsin Kuo
    • 2
    • 5
    • 6
    Email author
  • Ann-Lii Cheng
    • 2
    • 5
    • 6
  • Chiun-Sheng Huang
    • 3
    Email author
  1. 1.Division of Radiation Oncology, Department of Medical ImagingNational Taiwan University HospitalHsin-Chu CityTaiwan
  2. 2.Division of Radiation Oncology, Department of OncologyNational Taiwan University Hospital and National Taiwan University Cancer CenterTaipeiTaiwan
  3. 3.Department of SurgeryNational Taiwan University Hospital and National Taiwan University Cancer CenterTaipeiTaiwan
  4. 4.Department of PathologyNational Taiwan University Hospital and National Taiwan University Cancer CenterTaipeiTaiwan
  5. 5.Cancer Research CenterNational Taiwan University College of MedicineTaipeiTaiwan
  6. 6.Graduate Institute of OncologyNational Taiwan University College of MedicineTaipeiTaiwan

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