Annals of Surgical Oncology

, Volume 23, Issue 11, pp 3587–3592 | Cite as

Incidence and Risk Factors for Occult Level 3 Lymph Node Metastases in Papillary Thyroid Cancer

  • Sheila FraserEmail author
  • Nisar Zaidi
  • Olov Norlén
  • Anthony Glover
  • Schelto Kruijff
  • Mark Sywak
  • Leigh Delbridge
  • Stan B. Sidhu
Head and Neck Oncology



Papillary thyroid cancer (PTC) frequently disseminates into cervical lymph nodes. Lateral node involvement is described in up to 50 % patients undergoing prophylactic lateral neck dissection. This study aimed to assess this finding and identify which factors predict for occult lateral node disease.


Patients with fine needle aspiration–confirmed PTC (Bethesda V or VI), without evidence of cervical lymph node metastases, underwent a total thyroidectomy with prophylactic ipsilateral central and level 3 dissection. Level 3 nodes were removed by compartmental dissection or by sampling the sentinel nodes overlying the jugular vein, according to surgeon preference. Data were collected prospectively from January 2011 to August 2014. Statistical analysis was performed by SPSS software.


A total of 137 patients underwent total thyroidectomy with prophylactic ipsilateral central and level 3 dissection for PTC. The incidence of occult level 3 disease was 30 % (41/137 patients). A total of 48 % of patients (66/137) harbored occult central neck disease. A total of 80.5 % of patients with pN1b disease had macrometastases (≥2 mm), and 15 % exhibited skip metastases with central compartment sparing. In patients with pN1b disease, a median of 6 level 3 nodes were retrieved, with an average involved nodal ratio of 0.29. Multivariate regression demonstrated risk factors for occult lateral neck metastasis include tumor size (odds ratio 1.1), upper pole tumors (odds ratio 6.6), and vascular invasion (odds ratio 3.2) (p < 0.05).


PTC is associated with a significant incidence of occult central and lateral nodal metastases. In patients undergoing prophylactic central neck dissection, inclusion of level 3 dissection should be considered in patients with large upper lobe cancers.


Papillary Thyroid Cancer Nodal Ratio Lateral Neck Central Neck Central Neck Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors declare no conflict of interest.


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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Sheila Fraser
    • 1
    Email author
  • Nisar Zaidi
    • 1
  • Olov Norlén
    • 2
  • Anthony Glover
    • 3
  • Schelto Kruijff
    • 4
  • Mark Sywak
    • 1
  • Leigh Delbridge
    • 1
  • Stan B. Sidhu
    • 1
    • 3
  1. 1.Endocrine Surgery Unit, Royal North Shore HospitalUniversity of SydneySt. LeonardsAustralia
  2. 2.Department of Surgical SciencesUppsala UniversityUppsalaSweden
  3. 3.Kolling Institute of Medical ResearchUniversity of SydneySt. LeonardsAustralia
  4. 4.Department of Surgical OncologyUniversity Medical Centre GroningenGroningenNetherlands

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