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Annals of Surgical Oncology

, Volume 22, Supplement 3, pp 1083–1092 | Cite as

Is Hepatic Resection for Non-colorectal, Non-neuroendocrine Liver Metastases Justified?

  • Katrin HoffmannEmail author
  • Sümeyra Bulut
  • Aysun Tekbas
  • Ulf Hinz
  • Markus W. Büchler
  • Peter Schemmer
Hepatobiliary Tumors

Abstract

Background

Discussions about the benefit of liver resection (LRx) for non-colorectal, non-neuroendocrine metastases are controversial. This study aimed to analyze the outcome of LRx for these patients and validate a previously published prognostic risk model.

Methods

The study analyzed 150 patients who underwent LRx for non-colorectal non-neuroendocrine (NCNN) metastases. Patients’ demographics, tumor characteristics, treatment options, and postoperative outcome were investigated. The Kaplan–Meier method and Cox regression models were used to assess survival and prognostic variables.

Results

After a median follow-up period of 61 months, 39 % of the patients were alive. The 30-day mortality rate was 0.7 %. The overall, disease-free, and intrahepatic recurrence-free survival rates were respectively 42, 29, and 51 % at 5 years and 28, 23, and 47 % at 10 years. The negative prognostic factors identified in the multivariate analysis were melanoma (p = 0.04), squamous tumors (p = 0.01), and a primary tumor liver metastasis, with an interval shorter than 2 years (p = 0.02), whereas the predictive prognostic factors identified were breast cancer (p = 0.04), stromal tumors (p = 0.03), and major LRx (p = 0.04). The prognostic risk score stratified patients into low risk (0–3 points: n = 50; 5-year overall survival [OS] 58 %), medium risk (4–6 points: n = 91; 5-year OS 35 %), and high risk (≥7 points: n = 9; 5-year OS, 33 %) groups (p = 0.01).

Conclusion

Liver resection for patients with NCNN metastases is a safe treatment option. More than 25 % of patients can achieve a long-term survival of 10 years when the histology of the primary tumor and the surrogates for the individual biologic tumor behavior are taken into account. Exclusion of patients with NCNN liver metastases from surgical therapy is no longer justified.

Keywords

Liver Metastasis Liver Resection Median Survival Time Extrahepatic Recurrence Periampullary Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

There are no conflicts of interest.

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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Katrin Hoffmann
    • 1
    Email author
  • Sümeyra Bulut
    • 1
  • Aysun Tekbas
    • 1
  • Ulf Hinz
    • 1
  • Markus W. Büchler
    • 1
  • Peter Schemmer
    • 1
  1. 1.Department of General, Visceral, and Transplant SurgeryUniversity Hospital HeidelbergHeidelbergGermany

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