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Annals of Surgical Oncology

, Volume 22, Issue 10, pp 3289–3295 | Cite as

Normal Axillary Ultrasound Excludes Heavy Nodal Disease Burden in Patients with Breast Cancer

  • Rubie Sue JacksonEmail author
  • Charles Mylander
  • Martin Rosman
  • Reema Andrade
  • Kristen Sawyer
  • Thomas Sanders
  • Lorraine Tafra
Breast Oncology

Abstract

Background

Axillary lymph node stage is important in guiding adjuvant treatment for breast cancer. The role of axillary ultrasound (AUS) in axillary staging is uncertain.

Methods

From an institutional database, all newly diagnosed invasive breast carcinomas from February 1, 2011 to October 31, 2014 were identified; exclusions were for stage IV disease, palpable adenopathy, or receipt of neoadjuvant chemotherapy. AUS findings, categorized as suspicious versus not suspicious, were correlated with the number of nodal metastasis from surgical pathology. The false-negative rate of nonsuspicious AUS for identifying ≥3 lymph nodes positive on final pathology was calculated.

Results

A total of 513 cancers were included. Overall, 400 AUSs were not suspicious (78 %), and 113 were suspicious (22 %). The sensitivity and specificity of AUS for predicting ≥3 nodal metastasis were 71 and 83 %, respectively. The false-negative rate for detecting ≥3 nodal metastasis was 4 %. False-negative rate was higher for lobular versus nonlobular carcinomas (12.0 vs. 2.3 %, p = 0.004) and for pT2–pT4 tumors versus pT1 tumors (8.2 vs. 1.7 %, p = 0.005).

Conclusions

Patients with normal axillary physical exam and ultrasound rarely harbor a large nodal disease burden. Randomized trials of sentinel lymph node biopsy versus no axillary surgery in patients with normal AUS must be powered for subgroup analysis of patients with invasive lobular carcinoma and pT2–pT4 tumors. Preoperative identification of nodal metastasis may decrease the need for second surgeries and identify candidates for neoadjuvant chemotherapy. AUS is a noninvasive means of predicting disease burden preoperatively and as such is a powerful tool to individualize treatment plans.

Keywords

Sentinel Lymph Node Sentinel Lymph Node Biopsy Axillary Lymph Node Dissection Lymphovascular Invasion Invasive Lobular Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosure

None.

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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Rubie Sue Jackson
    • 1
    Email author
  • Charles Mylander
    • 1
  • Martin Rosman
    • 1
  • Reema Andrade
    • 1
  • Kristen Sawyer
    • 1
  • Thomas Sanders
    • 1
  • Lorraine Tafra
    • 1
  1. 1.The Breast CenterAnne Arundel Medical CenterAnnapolisUSA

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