Annals of Surgical Oncology

, Volume 22, Issue 13, pp 4363–4370 | Cite as

The Platelet-to-Lymphocyte Ratio Versus Neutrophil-to-Lymphocyte Ratio: Which is Better as a Prognostic Factor in Gastric Cancer?

  • Eun Young Kim
  • Jin Won Lee
  • Han Mo Yoo
  • Cho Hyun Park
  • Kyo Young Song
Gastrointestinal Oncology



As indicators of the systemic inflammatory response, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been proposed to predict the clinical outcome in some cancers. The purpose of this study was to investigate the impact of NLR and PLR on the prognosis of gastric cancer.


From 2000 to 2009, 1986 consecutive patients who underwent curative surgery for gastric cancer were enrolled. The optimal cutoff value of PLR and NLR was determined according to receiver operating characteristic analysis. We categorized the patients into the high or low PLR and NLR group based on the cutoff value, and the clinical features of these two groups were comparatively analyzed.


The high NLR and PLR groups were significantly associated with poor prognosis. The NLR was an independent prognostic factor for overall survival [hazard ratio (HR) = 1.403; p = 0.023]; however, the PLR was not (p = 0.788).


Although both the PLR and NLR can reflect the prognosis, the NLR is more predictive of overall survival than the PLR.


Gastric Cancer Overall Survival Early Gastric Cancer Laparoscopic Gastrectomy Remnant Gastric Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors are grateful for the statistics related consultation provided by the Catholic Research Coordinating Center’s Department of Biostatistics and also thank Hyun Kyo Kim for collection and assembly of data.


No disclosure of any commercial, financial, or material support.


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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Eun Young Kim
    • 1
  • Jin Won Lee
    • 1
  • Han Mo Yoo
    • 1
  • Cho Hyun Park
    • 1
  • Kyo Young Song
    • 1
  1. 1.Division of Gastrointestinal Surgery, Department of Surgery, College of Medicine, Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoulKorea

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