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Annals of Surgical Oncology

, Volume 22, Issue 6, pp 1996–2002 | Cite as

Hospitalization for Inflammatory Bowel Disease is Associated with Increased Risk of Breast Cancer: A Nationwide Cohort Study of an Asian Population

  • Ming-Shian Tsai
  • Hsin-Pao Chen
  • Chao-Ming Hung
  • Po-Huang Lee
  • Cheng-Li Lin
  • Chia-Hung Kao
Breast Oncology
  • 298 Downloads

Abstract

Purpose

To learn whether women with inflammatory bowel disease (IBD) exhibit a higher risk of breast cancer.

Methods

We identified 4,856 women with IBD symptoms from 1998 to 2008 and 19,424 control patients without the disorder, frequency matched by age, sex, and admission year. Both cohorts were followed-up until the end of 2010 to estimate the risk of breast cancer.

Results

Overall, the incidence of breast cancer was similar in the IBD and control cohorts (1.31 vs. 1.25 per 1,000 person-years). The adjusted hazard ratio of breast cancer was 0.95 (95 % confidence interval 0.66–1.36) for the IBD patients. Further analysis revealed that neither Crohn disease nor ulcerative colitis was associated with the risk of developing breast cancer in women. The age-specific analysis indicated that the incidence of breast cancer was highest in the 45- to 65-year-old age group in both cohorts. The incidence of breast cancer was significantly increased in patients who required hospitalization twice or more per year, compared with the control cohort (adjusted hazard ratio 8.45; 95 % confidence interval 4.64–15.4). Moreover, age-specific analysis showed that patients aged less than 65 years old (≤44 or 45–65 years of age) exhibited a strong association between IBD hospitalization and breast cancer risk.

Conclusions

The risk of breast cancer was positively proportional to the frequency of admission for IBD. Therefore, careful surveillance of breast cancer should be sought for female IBD patients with 2 or more annual hospitalizations.

Keywords

Breast Cancer Inflammatory Bowel Disease Breast Cancer Risk Inflammatory Bowel Disease Patient Crohn Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This study was partially supported by study projects of China Medical University (CMU102-BC-2); Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW103-TDU-B-212-113002), Health and welfare surcharge of tobacco products, China Medical University Hospital Cancer Research Center of Excellence (MOHW103-TD-B-111-03, Taiwan); and the International Research-Intensive Centers of Excellence in Taiwan (NSC101-2911-I-002-303). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Disclosure

The authors declare no conflict of interest.

Supplementary material

10434_2014_4198_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 15 kb)

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Ming-Shian Tsai
    • 1
  • Hsin-Pao Chen
    • 2
  • Chao-Ming Hung
    • 1
  • Po-Huang Lee
    • 1
  • Cheng-Li Lin
    • 3
    • 4
  • Chia-Hung Kao
    • 5
    • 6
  1. 1.Department of General SurgeryE-Da Hospital and I-Shou UniversityKaohsiungTaiwan
  2. 2.Department of Colorectal SurgeryE-Da Hospital and I-Shou UniversityKaohsiungTaiwan
  3. 3.Management Office for Health DataChina Medical University HospitalTaichungTaiwan
  4. 4.College of MedicineChina Medical UniversityTaichungTaiwan
  5. 5.Graduate Institute of Clinical Medical Science and School of Medical, College of MedicineChina Medical UniversityTaichungTaiwan
  6. 6.Department of Nuclear Medicine and PET CenterChina Medical University HospitalTaichungTaiwan

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