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Annals of Surgical Oncology

, Volume 21, Issue 12, pp 3963–3969 | Cite as

Does Obesity Affect Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Disseminated Mucinous Appendiceal Neoplasms?

  • Patricio M. Polanco
  • Alvaro I. Sanchez
  • Lekshmi Ramalingam
  • Heather Jones
  • Amer Zureikat
  • Matthew Holtzman
  • Steven Ahrendt
  • James Pingpank
  • Herbert J. Zeh
  • David L. Bartlett
  • Haroon A. Choudry
Gastrointestinal Oncology

Abstract

Background

Obesity has been described as a risk factor for surgical complications and may play a prominent role in the progression, recurrence, and survival rates of various cancers. Our objective was to investigate the impact of being overweight or obese on perioperative and oncologic outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for peritoneal carcinomatosis (PC) from mucinous appendiceal neoplasms (MAN).

Methods

From a prospectively maintained database (2001–2010) of CRS/HIPEC for PC from MAN, we evaluated the body mass index (BMI) of patients, categorizing them into normal weight (NW < 25 kg/m2), overweight (OW = 25 to 29.9 kg/m2), and obese (OB ≥ 30 kg/m2). We compared the perioperative and oncologic outcomes among groups.

Results

Of the 282 patients in the database, 234 had BMI data available, and 81, 79, and 74 patients were categorized as NW, OW, and OB, respectively. Although there was a trend toward increased risk of overall complications, wound infections, deep vein thrombosis, respiratory and renal complications, and anastomotic leaks in the OW and OB groups, these differences only achieved statistical significance for renal (p = 0.03) and pulmonary (p = 0.02) complications in the OW and OB groups, respectively. The 5-year survival rate for NW, OW, and OB patients was 63.9, 48, and 54.4 %, respectively (p = 0.63). The median time to progression was 21.1 (NW), 21.7 (OW), and 23.9 (OB) months (p = 0.83).

Conclusions

OW and OB patients may have an increased risk of renal and pulmonary complications, respectively. Obesity has no major impact on perioperative mortality and long-term oncologic outcomes in patients undergoing CRS/HIPEC for MAN.

Keywords

Body Mass Index Peritoneal Carcinomatosis Body Mass Index Category Body Mass Index Group Complete Cytoreduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosure

None.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Patricio M. Polanco
    • 1
  • Alvaro I. Sanchez
    • 1
  • Lekshmi Ramalingam
    • 1
  • Heather Jones
    • 1
  • Amer Zureikat
    • 1
  • Matthew Holtzman
    • 1
  • Steven Ahrendt
    • 1
  • James Pingpank
    • 1
  • Herbert J. Zeh
    • 1
  • David L. Bartlett
    • 1
  • Haroon A. Choudry
    • 1
  1. 1.Division of Surgical OncologyUniversity of PittsburghPittsburghUSA

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