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Annals of Surgical Oncology

, Volume 21, Issue 11, pp 3557–3563 | Cite as

Prognostic Factors and Outcome of Spermatic Cord Sarcoma

  • Stefano Radaelli
  • Anant Desai
  • James Hodson
  • Chiara Colombo
  • Keith Roberts
  • David Gourevitch
  • Alessandro Gronchi
Bone and Soft Tissue Sarcomas

Abstract

Purpose

To evaluate management and outcome in a large series of patients with spermatic cord sarcomas (SCS), a rare malignancy.

Methods

Eighty-two patients with localized SCS treated at two dedicated sarcoma units between 1992 and 2013 were included. Disease-specific survival (DSS) and crude cumulative incidence of local recurrence and distant metastases (DM) were estimated by Kaplan–Meier plots and log rank tests.

Results

Median follow-up was 33 months (interquartile range 13–72 months). Sixty-one patients presented with primary disease. Liposarcoma was the most common histotype, but surprisingly, 37 % of tumors were of high grade. Seventeen patients (21 %) received radiotherapy and 12 patients (15 %) chemotherapy. Five-year DSS for the whole series was 92 % [95 % confidence interval (CI) 83–97]. Five-year rates of local recurrence and DM were 26 % (95 % CI 15–42) and 24 % (95 % CI 15–38), respectively. Tumor grade was found to be a significant predictor of both DSS and DM (both p < 0.001). Quality of surgical margins was proved to affect the local outcome (p = 0.025), while the rates of distant metastases were found to differ significantly by histology (p = 0.010). Exclusively in the liposarcoma subgroup, quality of surgical margins was also directly associated with DSS (p = 0.043).

Conclusions

Wide excision of the tumor is critical for cure, especially in the liposarcoma subgroup. The role of radiotherapy and chemotherapy is not established.

Keywords

Local Recurrence Distant Metastasis Liposarcoma Soft Tissue Sarcoma Internal Inguinal Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors declare no conflict of interest.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Stefano Radaelli
    • 1
  • Anant Desai
    • 2
  • James Hodson
    • 3
  • Chiara Colombo
    • 1
  • Keith Roberts
    • 2
  • David Gourevitch
    • 2
  • Alessandro Gronchi
    • 1
  1. 1.Sarcoma Service, Department of SurgeryFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  2. 2.Department of Surgery, Midland Abdominal and Retroperitoneal Sarcoma UnitQueen Elizabeth HospitalBirminghamUK
  3. 3.Department of StatisticsQueen Elizabeth HospitalBirminghamUK

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