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Annals of Surgical Oncology

, Volume 21, Issue 9, pp 2981–2986 | Cite as

Does Completion Thyroidectomy Improve the Outcome of Patients with Minimally Invasive Follicular Carcinoma of the Thyroid?

  • Kiminori SuginoEmail author
  • Kaori Kameyama
  • Mitsuji Nagahama
  • Wataru Kitagawa
  • Hiroshi Shibuya
  • Keiko Ohkuwa
  • Takashi Uruno
  • Junko Akaishi
  • Akifumi Suzuki
  • Chie Masaki
  • Ken-ichi Matsuzu
  • Michikazu Kawano
  • Koichi Ito
Endocrine Tumors

Abstract

Background

The diagnosis of minimally invasive follicular thyroid carcinoma (MIFTC) is often made histologically after thyroid lobectomy. We attempted to determine whether completion thyroidectomy should be considered necessary for all patients diagnosed with MIFTC after thyroid lobectomy.

Methods

The subjects of this study were a total of 324 patients who underwent thyroid lobectomy as initial surgery at our institution between 1989 and 2010 and diagnosed histologically as MIFTC. Completion thyroidectomy was performed on 101 patients, and the other 223 patients were followed up without further treatments. Cumulative cause-specific survival (CSS) rates and distant-metastasis-free survival (DMFS) rates were calculated by the Kaplan–Meier method. Differences between groups were analyzed for statistical significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazards model.

Results

During the follow-up period, 39 patients were diagnosed with distant metastasis, and 7 patients died of their disease. Age at the initial surgery was found to be a significant factor related to DMFS in both the univariate and multivariate analysis and to also be related to CSS in the univariate analysis. Completion thyroidectomy did not have a significant effect on DMFS or CSS according to the results of the univariate analysis, but it had significant effect on DMFS according to the results of the multivariate analysis.

Conclusions

Although we were unable to demonstrate sufficient statistical evidence that completion thyroidectomy improved the outcome of MIFTC patients, it is noteworthy none of the patient who underwent completion thyroidectomy died of the disease.

Keywords

Distant Metastasis Papillary Thyroid Carcinoma Vascular Invasion Total Thyroidectomy National Cancer Comprehensive Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

The authors declare that no competing financial interests exist.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Kiminori Sugino
    • 1
    Email author
  • Kaori Kameyama
    • 2
  • Mitsuji Nagahama
    • 1
  • Wataru Kitagawa
    • 1
  • Hiroshi Shibuya
    • 1
  • Keiko Ohkuwa
    • 1
  • Takashi Uruno
    • 1
  • Junko Akaishi
    • 1
  • Akifumi Suzuki
    • 1
  • Chie Masaki
    • 1
  • Ken-ichi Matsuzu
    • 1
  • Michikazu Kawano
    • 1
  • Koichi Ito
    • 1
  1. 1.Department of SurgeryIto HospitalTokyoJapan
  2. 2.Division of Diagnostic PathologyKeio University HospitalTokyoJapan

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