Annals of Surgical Oncology

, Volume 21, Issue 1, pp 277–283 | Cite as

Lymph Node Ratio of the Central Compartment is a Significant Predictor for Locoregional Recurrence After Prophylactic Central Neck Dissection in Patients with Thyroid Papillary Carcinoma

  • In Sun Ryu
  • Chan Il Song
  • Seung-Ho Choi
  • Jong-Lyel Roh
  • Soon Yuhl Nam
  • Sang Yoon Kim
Endocrine Tumors



Lymph node ratio (LNR) is an important prognosis factor in many solid cancers, but there have been few reports of LNR in papillary thyroid carcinoma (PTC). This study investigated LNR of the central compartment to determine whether LNR has clinical significance as a prognostic predictor for recurrence after prophylactic central neck dissection (pCND) in patients with PTC.


The study includes 295 consecutive patients who underwent total thyroidectomy with bilateral pCND, which was pathologically diagnosed as N1a PTC. LNR was calculated as the ratio of positive LN to total LN removed.


LNR of 0.65 was significantly meaningful for recurrence when three or more LNs were collected (P < 0.001). The 10-year estimated recurrence-free survival rates were 98.6 % for patients with LNR ≤0.65 and 75.4 % for patients with LNR >0.65 (P < 0.001). Univariate analysis revealed that increasing tumor size and LNR >0.65 were significantly associated with recurrence (P < 0.05 each). No significant association with recurrence was found for age ≥45 years, male gender, microscopic extrathyroidal extension, coexistent chronic lymphocytic thyroiditis, T classification, multicentricity, number of positive LN, and extranodal extension (P > 0.05 each). The only independent variable for recurrence identified by multivariate analysis was LNR >0.65 (P < 0.001).


LNR may be a useful predictor to stratify the likelihood of recurrence after pCND in patients with pathologic N1a PTC.


Papillary Thyroid Carcinoma Positive Lymph Node Locoregional Recurrence Lymph Node Ratio Cervical Lymph Node Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by grants from the Bio and Medical Technology Department Program of the National Research Foundation funded by the Korean Government (MEST; 2012028788) and the Intramural Research Program (Theragnosis) of KIST.


The authors declare no conflict of interest.

Supplementary material

10434_2013_3258_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 16 kb)


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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • In Sun Ryu
    • 1
  • Chan Il Song
    • 1
  • Seung-Ho Choi
    • 1
  • Jong-Lyel Roh
    • 1
  • Soon Yuhl Nam
    • 1
  • Sang Yoon Kim
    • 1
    • 2
  1. 1.Department of Otolaryngology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea
  2. 2.Biomedical Research InstituteKorea Institute of Science and TechnologySeoulKorea

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