Annals of Surgical Oncology

, Volume 21, Issue 1, pp 284–291 | Cite as

Long-Term Survival After Adrenalectomy for Stage I/II Adrenocortical Carcinoma (ACC): A Retrospective Comparative Cohort Study of Laparoscopic Versus Open Approach

  • Gianluca Donatini
  • Robert Caiazzo
  • Christine Do Cao
  • Sebastien Aubert
  • Carlos Zerrweck
  • Ziad El-Kathib
  • Thomas Gauthier
  • Emmanuelle Leteurtre
  • Jean-Louis Wemeau
  • Marie Christine Vantyghem
  • Bruno Carnaille
  • Francois Pattou
Endocrine Tumors



Laparoscopic adrenalectomy (LA) is the standard treatment for benign adrenal lesions. The laparoscopic approach has also been increasingly accepted for adrenal metastases but remains controversial for adrenocortical carcinoma (ACC). In a retrospective cohort study we compared the outcome of LA versus open adrenalectomy (OA) in the treatment of stage I and II ACC.


This was a double cohort study comparing the outcome of patients with stage I/II ACC and a tumor size <10 cm submitted to LA or OA at Lille University Hospital referral center from 1985 to 2011. Main outcomes analyzed were: postoperative morbidity, overall survival, and disease-free survival.


Among 111 consecutive patients operated on for ACC, 34 met the inclusion criteria. LA and OA were performed in 13 and 21 patients, respectively. Baseline patient characteristics (gender, age, tumor size, hormonal secretion) were similar between groups. There was no difference in postoperative morbidity, but patients in LA group were discharged earlier (p < 0.02). After a similar follow-up (66 ± 52 for LA and 51 ± 43 months for OA), Kaplan–Meier estimates of disease-specific survival and disease-free survival were identical in both groups (p = 0.65, p = 0.96, respectively).


LA was associated with a shorter length of stay and did not compromise the long-term oncological outcome of patients operated on for stage I/II ACC ≤ 10 cm ACC. Our results suggest that LA can be safely proposed to patients with potentially malignant adrenal lesions smaller than 10 cm and without evidence of extra-adrenal extension.


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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • Gianluca Donatini
    • 1
  • Robert Caiazzo
    • 1
  • Christine Do Cao
    • 2
  • Sebastien Aubert
    • 3
  • Carlos Zerrweck
    • 1
  • Ziad El-Kathib
    • 1
  • Thomas Gauthier
    • 1
  • Emmanuelle Leteurtre
    • 3
  • Jean-Louis Wemeau
    • 2
  • Marie Christine Vantyghem
    • 2
  • Bruno Carnaille
    • 1
  • Francois Pattou
    • 1
    • 4
  1. 1.Department of General and Endocrine SurgeryLille Regional University HospitalLilleFrance
  2. 2.Department of EndocrinologyLille Regional University HospitalLilleFrance
  3. 3.Department of PathologyLille Regional University HospitalLilleFrance
  4. 4.Chirurgie Générale et EndocrinienneHôpital Claude Huriez, Lille Regional University HospitalLille CedexFrance

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