Annals of Surgical Oncology

, Volume 20, Issue 10, pp 3279–3285 | Cite as

Treatment Efficacy with Accelerated Partial Breast Irradiation (APBI): Final Analysis of the American Society of Breast Surgeons MammoSite® Breast Brachytherapy Registry Trial

  • Chirag Shah
  • Shahed Badiyan
  • J. Ben Wilkinson
  • Frank Vicini
  • Peter Beitsch
  • Martin Keisch
  • Douglas Arthur
  • Maureen Lyden
Breast Oncology

Abstract

Background

The purpose of this study was to examine data on treatment efficacy, cosmesis and toxicities for the final analysis of the American Society of Breast Surgeons MammoSite® breast brachytherapy registry trial.

Methods

A total of 1,449 cases of early-stage breast cancer underwent breast conserving therapy. The single-lumen MammoSite® device was used to deliver accelerated partial breast irradiation (APBI) (34 Gy in 3.4 Gy fractions). Of these, 1,255 cases (87 %) had invasive breast cancer (IBC) and 194 cases had DCIS. Median follow-up was 63.1 months with 45 % of all patients having follow-up of 6 years or longer.

Results

There were 41 cases (2.8 %) that developed an ipsilateral breast tumor recurrence (IBTR) for a 5-year actuarial rate of 3.8 % (3.7 % for IBC and 4.1 % for DCIS). Tumor size (odds ratio [OR] = 1.1, p = 0.03) and estrogen receptor negativity (OR = 3.0, p = 0.0009) were associated with IBTR, while a trend was noted for positive margins (OR = 2.0, p = 0.06) and cautionary/unsuitable status compared with suitable status (OR = 1.8, p = 0.07). The percentage of patients with excellent/good cosmetic results at 60, 72, and 84 months was 91.3, 90.5, and 90.6 %, respectively. The overall rates of fat necrosis and infections remained low at 2.5 and 9.6 % with few late toxicity events beyond 2 years. The overall symptomatic seroma rate was 13.4 and 0.6 % beyond 2 years.

Conclusions

The final analysis of treatment efficacy, cosmesis, and toxicity from the American Society of Breast Surgeons MammoSite® breast brachytherapy registry trial confirms previously noted excellent results and compares favorably with other forms of APBI with similar follow-up and to outcomes seen in selected patients treated with whole breast irradiation.

Notes

Acknowledgment

The MammoSite® breast brachytherapy registry trial was supported in part by a Grant by Hologic, Inc., Bedford, MA. Hologic, Inc. had no access to or influence on the data, analysis, or conclusions of this paper prior to publication.

Conflict of interest

There are no conflicts of interest to declare except Martin Keisch, M.D.: Consultant/Advisory Board, Hologic, Inc., Bedford, Massachusetts.

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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • Chirag Shah
    • 1
  • Shahed Badiyan
    • 1
  • J. Ben Wilkinson
    • 2
  • Frank Vicini
    • 3
  • Peter Beitsch
    • 4
  • Martin Keisch
    • 5
  • Douglas Arthur
    • 6
  • Maureen Lyden
    • 7
  1. 1.Department of Radiation OncologySumma Health SystemAkronUSA
  2. 2.Department of Radiation OncologyOakland University William Beaumont School of MedicineRoyal OakUSA
  3. 3.Michigan Healthcare Professionals/21st Century OncologyFarmington HillsUSA
  4. 4.Dallas Surgical GroupDallasUSA
  5. 5.Cancer HealthCare AssociatesUniversity of Miami HospitalMiamiUSA
  6. 6.Department of Radiation Oncology, Massey Cancer CenterVirginia Commonwealth UniversityRichmondUSA
  7. 7.Biostat International, IncTampaUSA

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