Annals of Surgical Oncology

, Volume 20, Issue 13, pp 4113–4120 | Cite as

Operative Risks Associated with Contralateral Prophylactic Mastectomy: A Single Institution Experience

  • Megan E. Miller
  • Tomasz Czechura
  • Brigid Martz
  • Mary E. Hall
  • Catherine Pesce
  • Nora Jaskowiak
  • David J. Winchester
  • Katharine YaoEmail author
Breast Oncology



The purpose of this study was to determine if newly diagnosed breast cancer patients undergoing contralateral prophylactic mastectomy (CPM) experience more complications than patients undergoing unilateral mastectomy (UM).


A total of 600 patients underwent either UM or CPM between January 2009 and March 2012 for unilateral breast cancer. Operative complications were classified as minor (aspirations, infection requiring antibiotics, partial flap and nipple necrosis, minor bleeding, delayed wound healing) or major (hematoma or seroma requiring operation, infection requiring rehospitalization, blood product transfusion, total flap or nipple loss, implant removal), mixed (both minor and major complications), or multiple. Chi-square and multivariate logistic regressions were used for the analysis.


Of the 600 patients, 391 (65 %) underwent UM and 209 (35 %) underwent CPM. Across all complication groups, there were significantly more complications in the CPM group versus the UM group (41.6 vs. 28.6 %, p = 0.001). Major complications alone were significantly greater in the CPM versus the UM group (13.9 vs. 4.1 %, p < 0.001). When adjusting for age, body mass index, smoking and diabetes history, AJCC stage, reconstruction, previous radiation therapy, and adjuvant therapy, CPM patients were 1.5 times more likely to have any complication (odds ratio [OR] 1.53; 95 % CI 1.04–2.25, p = 0.029) and 2.7 times more likely to have a major complication compared with UM patients (OR 2.66; 95 % CI 1.37–5.19, p = 0.004).


CPM patients have an increased risk of complications, especially major complications requiring rehospitalization or reoperation. These complications may influence patient and physician decisions to choose CPM.


Contralateral Prophylactic Mastectomy Operative Complication Prophylactic Mastectomy Time High Risk Bilateral Mastectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to acknowledge the Auxiliary of Evanston and Glenbrook Hospitals at NorthShore University HealthSystem who provided generous support for this work.


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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • Megan E. Miller
    • 1
  • Tomasz Czechura
    • 2
  • Brigid Martz
    • 2
  • Mary E. Hall
    • 2
  • Catherine Pesce
    • 1
    • 2
  • Nora Jaskowiak
    • 1
  • David J. Winchester
    • 1
    • 2
  • Katharine Yao
    • 1
    • 2
    Email author
  1. 1.Department of SurgeryThe University of Chicago MedicineChicagoUSA
  2. 2.Breast Surgical Program, Department of SurgeryNorthShore University HealthSystemEvanstonUSA

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