Annals of Surgical Oncology

, Volume 20, Issue 11, pp 3596–3602

Thermal Ablation Versus Repeated Hepatic Resection for Recurrent Intrahepatic Cholangiocarcinoma

Hepatobiliary Tumors

DOI: 10.1245/s10434-013-3035-1

Cite this article as:
Zhang, SJ., Hu, P., Wang, N. et al. Ann Surg Oncol (2013) 20: 3596. doi:10.1245/s10434-013-3035-1



Repeated hepatic resection (HR) and thermal ablation therapy (TAT) are increasingly being used to treat recurrent intrahepatic cholangiocarcinoma (RICC). This study compared the efficacy and safety of these procedures for RICC treatment.


Patients were studied retrospectively after curative resection of RICCs by repeated HR (n = 32) or TAT (n = 77). Treatment effectiveness and prognosis were compared between the two treatment groups.


The repeated HR and TAT groups did not differ in their overall survival (OS; p = 0.996) or disease-free survival (DFS; p = 0.692) rates. However, among patients with recurrent tumors >3 cm in diameter, patients in the repeated HR group had a higher OS rate than patients in the TAT group (p = 0.037). The number of recurrent tumors and the recurrence interval were significant prognostic factors for OS. The major complications incidence rate was greater in the repeated HR group than in the TAT group (p < 0.001).


Repeated HR and TAT are both effective treatments for RICC with similar overall efficacies. TAT should be preferred in any cases when the RICC is ≤3 cm in diameter and technically feasible. However, for large tumors (>3 cm), repeated HR may be a better choice.

Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  1. 1.Minimal Invasion Therapy Department 1Eastern Hepatobiliary Surgery HospitalShanghaiChina
  2. 2.Division of Interventional Ultrasound, Department of Hepatobiliary SurgeryThe First Affiliated Hospital, Sun Yat-Sen UniversityGuangzhouChina

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