Annals of Surgical Oncology

, Volume 20, Issue 4, pp 1203–1215 | Cite as

Short- and Long-term Outcomes after Laparoscopic and Open Hepatectomy for Hepatocellular Carcinoma: A Global Systematic Review and Meta-analysis

  • Zi Yin
  • Xinxiang Fan
  • Hua Ye
  • Dong Yin
  • Jie WangEmail author
Hepatobiliary Tumors



Laparoscopic hepatectomy (LH) has been proposed as a safe and feasible treatment option for liver diseases. However, the short- and long-term outcomes of LH versus open hepatectomy (OH) for hepatocellular carcinoma (HCC) have not been adequately assessed. Thus, as another means of surgical therapy for hepatocellular carcinoma (HCC), we assessed the feasibility of performing LH as the standard procedure for disease in the left lateral lobe and peripheral right segments for HCC in selected patients.


Literature search included PubMed, Embase, Science Citation Index, SpringerLink, and secondary sources, from inception to March 2012, with no restrictions on languages or regions. The fixed-effects and random-effects models were used to measure the pooled estimates. The test of heterogeneity was performed by the Q statistic. Subgroup and sensitivity analyses were performed to explore heterogeneity between studies and to assess the effects of study quality.


A total of 1238 patients (LH 485, OH 753) from 15 studies were included. The pooled odds ratios for postoperative morbidity and incidence of negative surgical margin in LH were found to be 0.37 (95 % confidence interval [CI] 0.27–0.52; P < 0.01) and 1.63 (95 % CI 0.82–3.22; P = 0.16), respectively, compared with OH. Blood loss was significantly decreased in the LH (weighted mean difference −224.63; 95 % CI −384.87 to −64.39; P = 0.006). No significant difference was observed between the both groups for long-term outcomes of overall survival and recurrence-free survival.


In patients with solitary left lateral lobe/right peripheral subcapsular tumors treated with minor resection, this meta-analysis demonstrated that compared to OH, LH may have short-term advantages in terms of blood loss and postoperative morbidity for HCC. Both procedures have similar long-term outcomes. It may be time to consider changing the standard procedures for treatment of HCC in the left lateral lobe and peripheral subcapsular right segments in selected patients.


Liver Resection Postoperative Morbidity Pool Estimate Parenchymal Transection Laparoscopic Hepatectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was not supported by any pharmaceutical company or grants; the cost was borne by the authors’ institutions. The authors thank Prof. Yuantao Hao, Department of Medical Statistics, Sun Yat-sen University, Guangdong, China, for statistical advice; and Yan Jia, Medical Library of North Campus, Sun Yat-sen University, Guangdong, China, for the literature search. Neither of these persons received compensation for the work performed.

Supplementary material

10434_2012_2705_MOESM1_ESM.pdf (101 kb)
Supplementary material 1 (PDF 101 kb)


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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Zi Yin
    • 1
  • Xinxiang Fan
    • 2
  • Hua Ye
    • 1
  • Dong Yin
    • 3
  • Jie Wang
    • 1
    Email author
  1. 1.General Surgery Department, Cancer Research CenterSun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
  2. 2.Urology DepartmentSun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
  3. 3.Division of Hematology and OncologyCedars-Sinai Medical Center, University of California at Los Angeles School of MedicineLos AngelesUSA

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