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Annals of Surgical Oncology

, Volume 19, Issue 8, pp 2494–2499 | Cite as

Short-term Results and Long-term Oncologic Outcomes between Neoadjuvant Chemoradiotherapy and Adjuvant Postoperative Chemoradiotherapy for Stage III Rectal Cancer: A Case-matched Study

  • Jeonghyun Kang
  • Sung Min Jang
  • Jeong-Heum BaekEmail author
  • Won Suk Lee
  • Tae Ho Cho
Colorectal Cancer

Abstract

Purpose

To compare the short-term perioperative results and long-term oncologic outcomes between patients who underwent neoadjuvant chemoradiotherapy (NCRT) and patients who underwent postoperative adjuvant chemoradiotherapy (ACRT) for stage III rectal cancer.

Methods

From January 1997 to December 2008, a total of 47 patients who were diagnosed as clinical stage III rectal cancer followed by NCRT were matched according to age, gender, and operation method to 47 patients with pathologic stage III rectal cancer who underwent ACRT. Clinical characteristics, surgical and pathologic outcomes, postoperative complications and recovery, and oncologic outcomes were compared between the two groups.

Results

There were no significant differences in demographics or preoperative characteristics between the NCRT and ACRT groups. Though more protective ileostomies were performed in the NCRT group, there was no statistical difference in operation times between the two groups. Patients in the NCRT group had a smaller tumor size (P < 0.001) and a smaller number of lymph nodes retrieved (P < 0.001). No differences were observed with respect to morbidity and recovery outcomes between the two groups. During the median 58-month follow-up periods, the NCRT group showed better disease-free survival and overall survival than the ACRT group (P = 0.002, P = 0.001, respectively).

Conclusions

NCRT in comparison to ACRT did not increase the risk of postoperative morbidity and provided better disease-free and overall survival in stage III rectal cancer patients.

Keywords

Overall Survival Rectal Cancer Total Mesorectal Excision Rectal Cancer Patient Circumferential Resection Margin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Jeonghyun Kang
    • 1
  • Sung Min Jang
    • 2
  • Jeong-Heum Baek
    • 2
    Email author
  • Won Suk Lee
    • 2
  • Tae Ho Cho
    • 2
  1. 1.Department of SurgeryYonsei University College of MedicineSeoulKorea
  2. 2.Department of SurgeryGil Hospital, Gachon UniversityIncheonKorea

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