Annals of Surgical Oncology

, 18:3088 | Cite as

Focused Ultrasound Ablation for the Treatment of Breast Cancer

  • David R. BreninEmail author
American Society of Breast Surgeons


Advances in technology and changes in our understanding of tumor biology have allowed breast cancer treatment to evolve toward less disfiguring procedures. Noninvasive ablative therapy is a natural continuation of this trend. The following paper presents the concepts underpinning focused ultrasound ablation therapy for the treatment of breast cancer and reviews the investigative experience to date in the evaluation of this promising technique.


Breast Cancer Ablation Zone Modify Radical Mastectomy Treatment Zone Diagnostic Ultrasound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

Supplementary material 1 (MOV 4113 kb)


  1. 1.
    Graham SJ, Chen L, Leitch M, Peters RD, Bronskill MJ, Foster FS, Henkelman RM, Plewes DB. Quantifying tissue damage due to focused ultrasound heating observed by MRI. Magn Reson Med. 1999;41:321–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Hill CR, ter Haar GR. High intensity focused ultrasound: potential for cancer treatment. Br J Radiol. 1995;68:1296–303.PubMedCrossRefGoogle Scholar
  3. 3.
    Wu F, et al. Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. Ultrasound Med Biol. 2001;27:1099–106.PubMedCrossRefGoogle Scholar
  4. 4.
    Wu F, Wang Z-B, Cao Y-D, Chen W-Z, Bai J, Zou J-Z, Zhu H. A randomized clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer. 2003;89:2227–33.PubMedCrossRefGoogle Scholar
  5. 5.
    Wu F, Wang Z-B, Zhu H, Chen W-Z, Zou J-Z, Bai J, Li K-Q, Jin C-B, Xie F-L, Su H-B. Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer. Breast Cancer Res Treat. 2005;92:51–60.PubMedCrossRefGoogle Scholar
  6. 6.
    Furusawa H, Namba K, Thomsen S, Akiyama F, Bendet A, Tanaka C, Yasuda Y, Nakahara H. Magnetic resonance-guided focused ultrasound surgery of breast cancer: reliability and effectiveness. J Am Coll Surg. 2006;203:54–63.PubMedCrossRefGoogle Scholar
  7. 7.
    Gambos EC, Kacher DF, Furusawa H, Namba K. Breast focused ultrasound surgery with magnetic resonance guidance. Top Magn Reson Imaging. 2006;17:181–8.CrossRefGoogle Scholar
  8. 8.
    Gianfelice D, Khiat A, Amara M, Belblidia A, Boulanger Y. MR imaging-guided focused US ablation of breast cancer: histopathologic assessment of effectiveness-initial experience. Radiology. 2003;227:849–55.PubMedCrossRefGoogle Scholar
  9. 9.
    Gianfelice D, Khait A, Boulanger Y, Amara M, Beblidia A. Feasibility of magnetic resonance imaging-guided focused ultrasound surgery as an adjunct to tamoxifen therapy in high-risk surgical patients with breast carcinoma. J Vasc Interv Radiol. 2003;14:1275–82.PubMedGoogle Scholar
  10. 10.
    Gianfelice D, Khiat A, Amara M, Belblindia A, Boulanger Y. MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathological findings. Breast Cancer Res Treat. 2003;82:93–101.PubMedCrossRefGoogle Scholar
  11. 11.
    Zippel DB, Papa MZ. The use of MR imaging guided focused ultrasound in breast cancer patients; a preliminary phase one study and review. Breast Cancer. 2005;12:32–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Khiat A, Gianfelice D, Amara M, Boulanger Y. Influence of post-treatment delay on the evaluation of the response to focused ultrasound surgery of breast cancer by dynamic contrast enhanced MRI. Br J Radiol. 2006;79:308–14.PubMedCrossRefGoogle Scholar
  13. 13.
    Furusawa H, Namba K, Nakahara H, Tanaka C, Yasuda Y, Hirabara E, Imahariyama M, Komaki K. The evolving non-surgical ablation of breast cancer: MR guided focused ultrasound (MRgFUS). Breast Cancer. 2007;14:55–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Furusawa H. Treatment of breast cancer. Plenary session presented at the second international symposium on MR-guided focused ultrasound, October 2010, Washington, DC.Google Scholar
  15. 15.
    Wu F, Wang Z-B, Cao Y-D, Zhu X-Q, Zhy H, Chen W-Z, Zou J-Z. Wide local ablation of localized breast cancer using high intensity focused ultrasound. J Surg Oncol. 2007;96:130–6.PubMedCrossRefGoogle Scholar
  16. 16.
    Holland R, Veling SHJ, Mravunac M, Hendriks JHCL. Histologic multifocality of Tis, T1-2 breast carcinomas: implications for clinical trials of breast-conserving surgery. Cancer. 1985;56:979–90.PubMedCrossRefGoogle Scholar
  17. 17.
    Bland KL, Gass J, Klimberg VS. Radiofrequency, cryoablation, and other modalities for breast cancer ablation. Surg Clin North Am. 2007;87:539–50.PubMedCrossRefGoogle Scholar
  18. 18.
    Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–41.PubMedCrossRefGoogle Scholar
  19. 19.
    Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Agular M, Marubini E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–32.PubMedCrossRefGoogle Scholar
  20. 20.
    ACRIN 6674.Google Scholar

Copyright information

© Society of Surgical Oncology 2011

Authors and Affiliations

  1. 1.Division of Surgical OncologyUniversity of VirginiaCharlottesvilleUSA

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