Annals of Surgical Oncology

, 18:3110 | Cite as

Contralateral Prophylactic Mastectomy: Long-Term Consistency of Satisfaction and Adverse Effects and the Significance of Informed Decision-Making, Quality of Life, and Personality Traits

  • Marlene H. FrostEmail author
  • Tanya L. Hoskin
  • Lynn C. Hartmann
  • Amy C. Degnim
  • Joanne L. Johnson
  • Judy C. Boughey
American Society of Breast Surgeons



This study aims to evaluate the long-term consistency of satisfaction with contralateral prophylactic mastectomy (CPM) and adverse psychosocial effects as well as to explore the effect of informed decision-making, personality traits, and quality of life (QOL) on satisfaction.


A previously established cohort of women with unilateral breast cancer who had undergone CPM between 1960 and 1993 were surveyed using study-specific and standardized questionnaires at two follow-up time points. The first survey was a mean of 10.7 years and the second survey a mean of 20.2 years after CPM.


487 of the 583 women who responded to the first study were alive and resurveyed. Data from both surveys were available for 269 women. With longer follow-up, there was a small increase in the percentage of women satisfied (90%) and those who would choose CPM again (92%) (4% and 2% increase from first survey, respectively). Most adversely affected were body appearance (31%), feelings of femininity (24%), and sexual relationships (23%). Ninety-three percent of women felt they had made an informed decision. Perception of making an informed choice and current QOL were moderately associated with satisfaction with CPM (r = 0.37 and 0.37, respectively) while associations with trait anxiety and optimism were weak (r = 0.27 and 0.21, respectively).


Long-term satisfaction and adverse effects remained remarkably stable. It is important that women fully understand the benefits and adverse effects associated with CPM.


Body Image Personality Trait Trait Anxiety Contralateral Prophylactic Mastectomy Prophylactic Mastectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work is supported, in part, by grants from the Department of Defense (DAMD17-94-J-4216) and the National Cancer Institute (U10 CA 37404 and R01 CA80181).


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Copyright information

© Society of Surgical Oncology 2011

Authors and Affiliations

  • Marlene H. Frost
    • 1
    Email author
  • Tanya L. Hoskin
    • 2
  • Lynn C. Hartmann
    • 1
  • Amy C. Degnim
    • 3
  • Joanne L. Johnson
    • 4
  • Judy C. Boughey
    • 3
  1. 1.Department of Medical OncologyMayo ClinicRochesterUSA
  2. 2.Division of Biostatistics, Department of Health Sciences ResearchMayo ClinicRochesterUSA
  3. 3.Department of SurgeryMayo ClinicRochesterUSA
  4. 4.Cancer CenterMayo ClinicRochesterUSA

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