Abstract
Background
The rare patient diagnosed with pure ductal carcinoma-in-situ (DCIS) develops distant breast cancer metastases (DM). We sought to identify clinical and pathologic predictors of DM.
Methods
The clinical and pathologic characteristics of patients with DM after a diagnosis of pure DCIS from 1996 to 2009 were analyzed.
Results
Twenty five patients with DM after an initial diagnosis of DCIS were identified; 3 were treated at our institution and 22 were originally treated elsewhere. The rate of DM was 0.14% among 2,123 patients originally treated at our institution. Among all patients with DM, 73.7% had DCIS with necrosis, and 62% had DCIS that did not express estrogen receptor. Twenty-four percent of patients with DM were African American, compared to 11.5% of the total study population. The median time from DCIS to DM was 4.5 years. Sixteen patients (66%) had a preceding or simultaneous invasive locoregional recurrence (LRR); nine (34%) did not. At last follow-up, 14 patients (56%) had died of disease; median time to death was 2.4 years. No dominant variables could be identified in patients who developed DM with or without a LRR.
Conclusions
DM after a diagnosis of pure DCIS is rare. Although most patients with DM have a preceding invasive LRR, some present with subsequent DM alone. Further study is required to identify clinical and pathologic predictors of this more rapid disease progression.
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Acknowledgment
The University of Texas M. D. Anderson Cancer Center is supported in part by the National Institutes of Health through support grant CA016672.
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Roses, R.E., Arun, B.K., Lari, S.A. et al. Ductal Carcinoma-In-Situ of the Breast with Subsequent Distant Metastasis and Death. Ann Surg Oncol 18, 2873–2878 (2011). https://doi.org/10.1245/s10434-011-1707-2
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DOI: https://doi.org/10.1245/s10434-011-1707-2