Annals of Surgical Oncology

, Volume 18, Issue 3, pp 832–837 | Cite as

Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma

  • Yasunori AkutsuEmail author
  • Hisahiro Matsubara
  • Masayuki Kano
  • Akihiro Usui
  • Yasuo Yoneyama
  • Norimasa Ikeda
  • Aki Komatsu
  • Gulbostan Yusup
Thoracic Oncology



Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma.


Seventy-eight patients with primarily resected esophageal squamous cell carcinoma were enrolled onto this study, and gp96 expression was evaluated by immunohistochemical staining. The association of clinicopathological factors and patients’ survival was calculated by univariate (log rank test) and multivariate (Cox proportional hazard regression method) analyses.


Fifty-seven (73%) of 78 cases were gp96 positive, and 21 were negative (27%). The survival of patients with gp96-negative disease was significantly shorter (5-year survival, 22.9 months) than with gp96-positive disease (45.8 months; P = 0.049), and the multivariate analysis showed that gp96 negativity is an independent risk factor for poor survival (hazard ratio, 2.577; P = 0.040). Gp96-negative cases had more metastatic lymph nodes than did negative cases, especially in T1 cases (4.8 in gp96-negative cases vs. 0.84 in gp96-positive cases; P = 0.064)


The downregulation of gp96 expression is closely correlated with poor survival in esophageal squamous cell carcinoma.


Esophageal Cancer Esophageal Squamous Cell Carcinoma Metastatic Lymph Node Antitumor Immunity Esophageal Squamous Cell Carcinoma Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by a Grant-in-Aid for Young Scientists (B) 21791268, the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors declare that they have no conflicts of interest.


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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Yasunori Akutsu
    • 1
    Email author
  • Hisahiro Matsubara
    • 1
  • Masayuki Kano
    • 1
  • Akihiro Usui
    • 1
  • Yasuo Yoneyama
    • 1
  • Norimasa Ikeda
    • 1
  • Aki Komatsu
    • 1
  • Gulbostan Yusup
    • 1
  1. 1.Department of Frontier Surgery, Graduate School of MedicineChiba UniversityChibaJapan

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