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Annals of Surgical Oncology

, Volume 17, Issue 8, pp 2081–2089 | Cite as

Predictive Factors for Hypertrophy of the Future Remnant Liver After Selective Portal Vein Embolization

  • Thierry de Baere
  • Christophe Teriitehau
  • Frederic Deschamps
  • Laurence Catherine
  • Pramod Rao
  • Antoine Hakime
  • Anne Auperin
  • Diane Goere
  • Dominique Elias
  • Lukas Hechelhammer
Hepatobiliary Tumors

Abstract

Background

To analyze predictive factors of hypertrophy of the nonembolized future remnant liver (FRL) after transhepatic preoperative portal vein embolization (PVE) of the liver to be resected.

Materials and Methods

Age, gender, indocyanin green clearance test, chemotherapy before PVE, type of chemotherapy, operators, extent of PVE, radiofrequency ablation (RFA) associated with PVE, time delay between PVE and surgery, and platelet count were retrospectively evaluated as predictive factors for hypertrophy of FRL in 107 patients with malignant disease in noncirrhotic liver. PVE targeted the right liver lobe [n = 70] or the right liver lobe and segment IV [n = 37] when FRL/total liver volume ratio was below 25% in healthy liver or 40% in altered liver.

Results

After PVE, FRL volume significantly increased by 69%, from 344 ± 156 cm3 to 543 ± 192 cm3 (P < .0001). The degree of hypertrophy was negatively correlated with FRL volume (correlation coefficient = −0.55, P < .0001) and FRL/TFL ratio (correlation coefficient = −0.52, P < .0001) before PVE. Patients, who have undergone chemotherapy with platin agents prior to PVE, demonstrated lower hypertrophy (P = .048).

Conclusion

Hypertrophy after PVE is inversely correlated to initial FRL volume. Hypertrophy of the liver might be influenced by the systemic chemotherapeutic received before PVE.

Keywords

Portal Vein Embolization Future Remnant Liver Portal Branch Portal Vein Branch Future Remnant Liver Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The authors thank Joey Marie Robinson for editing the manuscript.

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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Thierry de Baere
    • 1
  • Christophe Teriitehau
    • 1
  • Frederic Deschamps
    • 1
  • Laurence Catherine
    • 1
  • Pramod Rao
    • 1
  • Antoine Hakime
    • 1
  • Anne Auperin
    • 2
  • Diane Goere
    • 3
  • Dominique Elias
    • 3
  • Lukas Hechelhammer
    • 1
  1. 1.Department of Interventional RadiologyInstitut Gustave RoussyVillejuifFrance
  2. 2.Department of BiostatisticsInstitut Gustave RoussyVillejuifFrance
  3. 3.Department of Surgical OncologyInstitut Gustave RoussyVillejuifFrance

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