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Annals of Surgical Oncology

, Volume 16, Issue 1, pp 159–170 | Cite as

Risk Stratification of Patients with Oral Cavity Squamous Cell Carcinoma and Contralateral Neck Recurrence Following Radical Surgery

  • Chun-Ta Liao
  • Shiang-Fu Huang
  • I-How Chen
  • Joseph Tung-Chieh Chang
  • Hung-Ming Wang
  • Shu-Hang Ng
  • Chuen Hsueh
  • Li-Yu Lee
  • Chih-Hung Lin
  • Ann-Joy Cheng
  • Tzu-Chen YenEmail author
Head and Neck Oncology

Abstract

Clinical outcome of patients with oral cavity squamous cell carcinoma (OSCC) and contralateral neck recurrence (CLNR) remains poor. We sought to identify factors associated with CLNR and incorporate them into a risk stratification scheme. Between January 1996 and June 2006, a total of 913 consecutive OSCC patients treated by radical surgery were investigated. Postoperative adjuvant therapy was performed in the presence of pathological risk factors. The duration of follow-up was at least 24 months in all surviving patients. Outcome measures were the 5-year CLNR and overall survival rates. In the entire study cohort, the 5-year CLNR rate was 7% (55/913). Specifically, it was 18% (17/132) in patients with local recurrence (LR), and 5% (38/781) in those without (P = 0.0002). In multivariate analysis, extracapsular spread (ECS) was the only independent risk factor for CLNR in patients with LR. Tumor subsite, poor differentiation, and presence of pN + disease were significant predictors of CLNR in patients without LR. We identified two groups of patients with high CLNR rates. The first group consisted of patients with ECS at the initial diagnosis and LR. The second group consisted of subjects with tongue cancer without LR harboring at least two risk factors. We conclude that, in patients who achieved local control, postoperative contralateral neck treatment is recommended for subjects with tongue cancer and at least two risk factors. Once LR occurs, contralateral neck treatment is recommended in patients with ECS.

Keywords

Neck Dissection Tongue Cancer Oral Cavity Cancer Oral Cavity Squamous Cell Carcinoma Neck Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This study was supported by grants NMRPG160031, CMRPG361051, and CMRPG370061 from the Chang Gung Memorial Hospital.

Conflicts of interest statement

The authors indicated no potential conflicts of interest.

Authors’ contributions

Conception and design: C.T. Liao, T.C. Yen.

Funding support: NMRPG160031, CMRPG361051, and CMRPG370061.

Administrative support: T.C. Yen.

Provision of study materials or patients: C.T. Liao, S.F. Huang, I.H. Chen, J.T.C. Chang, H.M. Wang, S.H. Ng, C. Hsueh, L.Y. Lee, C.H. Lin, A.J. Cheng, T.C. Yen.

Collection and assembly of data: C.T. Liao, S.F. Huang, I.H. Chen, J.T.C. Chang, H.M. Wang, S.H. Ng, C. Hsueh, L.Y. Lee, C.H. Lin, I.H. Chen, S.F. Huang, A.J. Cheng, T.C. Yen.

Data analysis and interpretation: C.T. Liao, T.C. Yen.

Manuscript writing: C.T. Liao, T.C. Yen.

Final approval of manuscript: C.T. Liao, T.C. Yen.

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Copyright information

© Society of Surgical Oncology 2008

Authors and Affiliations

  • Chun-Ta Liao
    • 1
    • 2
  • Shiang-Fu Huang
    • 1
    • 2
  • I-How Chen
    • 1
    • 2
  • Joseph Tung-Chieh Chang
    • 2
    • 3
  • Hung-Ming Wang
    • 2
    • 4
  • Shu-Hang Ng
    • 2
    • 5
  • Chuen Hsueh
    • 2
    • 6
  • Li-Yu Lee
    • 2
    • 6
  • Chih-Hung Lin
    • 2
    • 7
  • Ann-Joy Cheng
    • 2
    • 8
  • Tzu-Chen Yen
    • 2
    • 9
    Email author
  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  2. 2.Department of Head and Neck Oncology GroupChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  3. 3.Department of Radiation OncologyChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  4. 4.Department of Hema-OncologyChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  5. 5.Department of Diagnostic RadiologyChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  6. 6.Department of PathologyChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  7. 7.Department of Plastic and Reconstructive SurgeryChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  8. 8.Department of Medical Biotechnology, Biostatistics Consulting Center/Department of Public HealthChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC
  9. 9.Nuclear Medicine and Molecular Imaging CenterChang Gung Memorial Hospital and Chang Gung UniversityTaoyuanTaiwan, ROC

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