Annals of Surgical Oncology

, Volume 9, Issue 1, pp 27–34 | Cite as

The superiority of ratio-based lymph node staging in gastric carcinoma

  • Kentaro Inoue
  • Yasushi Nakane
  • Hitoshi Iiyama
  • Mutsuya Sato
  • Tatsuya Kanbara
  • Koji Nakai
  • Syunichiro Okumura
  • Keigo Yamamichi
  • Koshiro Hioki
Original Articles


Background: The need for a precise lymph node staging without stage migration is of paramount importance when comparing and evaluating international treatment results.

Methods: We reviewed 1019 patients who underwent R0 resection at Kansai Medical University between 1980 and 1997. The patients were classified according to the 1997 International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) pN classification or the N staging depending on the ratio between the number of excised and the number of involved lymph nodes (pN1, ≤25%; pN2, ≤50%; pN3, >50%).

Results: Among the 1997 UICC/AJCC pN subgroups, prognosis worsened with an increase in lymph node ratio. In contrast, the ratio-based classification showed more homogenous survival according to the number of involved lymph nodes. Multiple stepwise regression analysis showed that the ratio-based classification was the most significant prognostic factor, whereas the 1997 UICC/AJCC classification was not found to be an independent predictor of survival. In addition, the ratio-based classification showed a superiority to the 1997 UICC/AJCC classification with respect to stage migration.

Conclusions: Ratio-based lymph node staging is simple and gives more precise information for prognosis with fewer problems related to stage migration than the 1997 UICC/AJCC staging system.

Key Words:

Gastric carcinoma Lymph node classification Lymph node metastasis Prognostic factor TNM classification Lymph node ratio 


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Copyright information

© The Society of Surgical Oncology, Inc. 2002

Authors and Affiliations

  • Kentaro Inoue
    • 1
  • Yasushi Nakane
    • 1
  • Hitoshi Iiyama
    • 1
  • Mutsuya Sato
    • 1
  • Tatsuya Kanbara
    • 1
  • Koji Nakai
    • 1
  • Syunichiro Okumura
    • 1
  • Keigo Yamamichi
    • 1
  • Koshiro Hioki
    • 1
  1. 1.Second Department of SurgeryKansai Medical UniversityMoriguchi, OsakaJapan

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