Annals of Surgical Oncology

, Volume 12, Issue 1, pp 1–2 | Cite as

Less Is (Usually) More: When Is Amputation Appropriate for Treatment of Extremity Soft Tissue Sarcoma?



  1. 1.
    Rosenberg, SA, Tepper, J, Glatstein, E,  et al. 1982The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapyAnn Surg19630515PubMedGoogle Scholar
  2. 2.
    Fisher, B, Anderson, S, Redmond, CK,  et al. 1995Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancerN Engl J Med333145661CrossRefPubMedGoogle Scholar
  3. 3.
    Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer.1991The Department of Veterans Affairs Laryngeal Cancer Study GroupN Engl J Med324168590CrossRefGoogle Scholar
  4. 4.
    Droesch J, Flum DR, Mann GN. Wide local excision or abdomino-perineal resection as the initial treatment for anorectal melanoma? Am J Surg 2005 (in press)Google Scholar
  5. 5.
    Ghert, MA, Abudu, A, Driver, N,  et al. 2005The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremityAnn Surg Oncol12.(in press)Google Scholar
  6. 6.
    O’Sullivan, B, Davis, AM, Turcotte, R,  et al. 2002Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomized trialLancet359223541CrossRefPubMedGoogle Scholar
  7. 7.
    Davis, AM, O’Sullivan, B, Bell, RS,  et al. 2002Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcomaJ Clin Oncol2044727PubMedGoogle Scholar
  8. 8.
    Brooks, AD, Gold, JS, Graham, D,  et al. 2002Resection of the sciatic, peroneal, or tibial nerves: assessment of functional statusAnn Surg Oncol9417PubMedGoogle Scholar
  9. 9.
    Merimsky, O, Kollender, Y, Inbar, M,  et al. 2001Is forequarter amputation justified for palliation of intractable cancer symptoms?Oncology60559PubMedGoogle Scholar

Copyright information

© The Society of Surgical Oncology, Inc. 2005

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of WashingtonSeattle

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