Annals of Surgical Oncology

, Volume 11, Issue 4, pp 393–398

Peritonectomy and Intraperitoneal Hyperthermic Perfusion (IPHP): A Strategy That Has Confirmed its Efficacy in Patients with Pseudomyxoma Peritonei

  • Marcello Deraco
  • Dario Baratti
  • Maria Grazia Inglese
  • Biagino Allaria
  • Salvatore Andreola
  • Cecilia Gavazzi
  • Shigeki Kusamura
Original Articles

Abstract

Background: Pseudomyxoma peritonei (PMP) is a rare disease with a poor prognosis characterized by a complete redistribution of mucin within the peritoneal cavity. The aim of this multicentric study was to evaluate the survival, morbidity, toxicity, and mortality of patients with PMP treated by cytoreductive surgery (CRS) with intraperitoneal hyperthermic perfusion (IPHP).

Methods: Thirty-three patients with PMP (21 males and 12 females) were enrolled in a phase II clinical trial. One patient underwent surgery twice because of disease recurrence. CRS was performed with peritonectomy procedures. The closed abdomen technique was employed for IPHP with use of cisplatin (25 mg/m2/L) plus mitomycin-C (3.3 mg/m2/L) for 60 minutes under hyperthermic conditions (42.5°C).

Results: Thirty-one patients (92%) were optimally cytoreduced. Five-year overall survival, progression-free survival, and locoregional progression-free survival rates were 97%, 43%, and 59%, respectively. Grade II and grade III morbidity was observed in 5 patient (15%) and 6 patients (18%), respectively. There was one treatment-related death (3%), 21 days after treatment.

Conclusions: CRS associated with IPHP permitted complete tumor removal with an acceptable morbidity and mortality for patients with PMP. This study confirms the efficacy of the combined treatment in terms of long-term survival and local disease control.

Key Words:

Intraperitoneal hyperthermic perfusion Peritonectomy Pseudomyxoma peritonei 

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Copyright information

© The Society of Surgical Oncology, Inc. 2004

Authors and Affiliations

  • Marcello Deraco
    • 1
    • 6
  • Dario Baratti
    • 1
  • Maria Grazia Inglese
    • 2
  • Biagino Allaria
    • 3
  • Salvatore Andreola
    • 4
  • Cecilia Gavazzi
    • 5
  • Shigeki Kusamura
    • 1
  1. 1.Department of Surgery, Melanoma and Sarcoma UnitNational Cancer Institute of MilanItaly
  2. 2.Department of AnesthesiologyNational Cancer Institute of MilanItaly
  3. 3.Department of Critical CareNational Cancer Institute of MilanItaly
  4. 4.Department of PathologyNational Cancer Institute of MilanItaly
  5. 5.Nutritional Care UnitNational Cancer Institute of MilanItaly
  6. 6.Unità Operativa Melanoma e SarcomaIstituto Nazionale per lo Studio e la Cura dei TumoriMilanItaly

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