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Annals of Surgical Oncology

, Volume 10, Issue 8, pp 916–921 | Cite as

Predictors of Long-Term Disease-Free Survival After Resection of Hepatocellular Carcinoma: Two Decades of Experience at Chang Gung Memorial Hospital

  • Chun-Nan Yeh
  • Wei-Chen Lee
  • Miin-Fu Chen
  • Pei-Kwei Tsay
Original Articles

Abstract

Background: Hepatocellular carcinoma (HCC) is a common disease in Taiwan. A high incidence of recurrence after hepatectomy is the most important cause of unsatisfactory results after resection of HCC. This study aimed to determine the clinicopathologic factors for predicting survival >5 years without recurrence in HCC patients treated with hepatectomy.

Methods: The clinical features of 46 patients with surgically resected HCC who survived >5 years without recurrence (group A) were reviewed. Also, comparison was made with the clinical features and factors influencing the outcome of 1046 cases of resected HCC who survived <5 years both with and without recurrence and for >5 years with recurrence (group B).

Results: Of 1092 cases of surgically resected HCC, 46 (4.5%) survived >5 years without recurrence. Univariate analysis revealed that absence of vascular invasion, satellite lesions, low histological grading of HCC, a lower rate of underlying liver cirrhosis, wider resection margins, and an uneventful postoperative course were frequent in group A patients compared with group B patients. Moreover, multivariate stepwise logistic regression analysis identified an absence of satellite lesions and an uneventful postoperative course as the two main independently significant predictors of HCC patients undergoing hepatectomy with long-term disease-free survival. The 1-, 3-, 5-, and 10-year survival rates of group A patients were 100%, 100%, 100%, and 84.1%, whereas those of group B patients were 73.5%, 47.9%, 29.0%, and 21.2%, respectively.

Conclusions: An absence of satellite lesions and an uneventful postoperative course are the two main independent predictors for long-term disease-free survival in HCC patients undergoing hepatic resection.

Key Words

Predictors Long-term disease-free survival Hepatic resection Hepatocellular carcinoma 

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Copyright information

© The Society of Surgical Oncology, Inc. 2003

Authors and Affiliations

  • Chun-Nan Yeh
    • 1
    • 3
  • Wei-Chen Lee
    • 1
  • Miin-Fu Chen
    • 1
  • Pei-Kwei Tsay
    • 2
  1. 1.Department of General SurgeryChang Gung Memorial Hospital, Chang Gung UniversityTaoyuanTaiwan
  2. 2.Department of Public Health and Center of BiostatisticsChang Gung UniversityTaoyuanTaiwan
  3. 3.Department of General SurgeryChang Gung Memorial HospitalKwei-ShanTaiwan

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