The Prognosis of T3N0 Colon Cancer Is Dependent on the Number of Lymph Nodes Examined
- 673 Downloads
Background: T3N0 colon cancer is the target of many adjuvant studies. Very few studies have examined the relationship of the number of lymph nodes examined to the prognosis of this stage. We examined data from the National Cancer Data Base (NCDB) to determine whether the number of examined lymph nodes is prognostic for T3N0 colon cancer.
Methods: A total of 35,787 prospectively collected cases of T3N0 colon cancer that were surgically treated and pathologically reported from 1985 to 1991 to the NCDB as T3N0M0 were analyzed.
Results: The 5-year relative survival rate for T3N0M0 colon cancer varied from 64% if 1 or 2 lymph nodes were examined to 86% if >25 lymph nodes were examined. Three strata of lymph nodes (1–7, 8–12, and ≥13) distinguished significantly different observed 5-year survival rates.
Conclusions: These results demonstrate that the prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. A minimum of 13 lymph nodes should be examined to label a T3 colon cancer as node negative. These data suggest that adjuvant trials for T3N0 colon cancer should stratify according to the number of lymph nodes examined.
Key WordsColon cancer T3N0 Lymph nodes Prognosis
Unable to display preview. Download preview PDF.
- 2.National Institutes of Health Consensus Statement. Adjuvant Therapy for Patients With Colon and Rectum Cancer. Bethesda, MD: National Institutes of Health, 1990.Google Scholar
- 3.Percy C, Van Holten V, Muir C. International Classification of Diseases of Oncology. 2nd ed. Geneva: World Health Organization, 1990.Google Scholar
- 5.Beahrs OH, Myers MH, Hutter RVP, Kennedy BJ, eds. Manual for Staging of Cancer: American Joint Committee on Cancer. 3rd ed. Philadelphia: Lippincott, 1988.Google Scholar
- 6.Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ, eds. Manual for Staging of Cancer: American Joint Committee on Cancer. 4th ed. Philadelphia: Lippincott, 1992.Google Scholar
- 11.Deleted in proof.Google Scholar
- 13.Wingo PA, Luke E, O’Brien K, et al. Population-based patterns of care studies: collaboration among state cancer registries, the American College of Surgeons, and the American Cancer Society. J Registry Manage 2001; 28: 5–16.Google Scholar