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Skin- and Eco-Friendly Hand Sanitizer: A Novel Composition of Natural Extracts to Prevent the Spread of Respiratory Viruses

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Abstract

Respiratory diseases caused by viruses are a serious global health threat. Although the use of hand sanitizers containing alcohol and synthetic antiseptic agents is recognized as an effective, simple, and low-cost measure to combat viral transmission, they can harm human health and the environment. Thus, this work aimed to study the efficacy of combining Camellia sinensis and Chamomilla recutita extracts in a skin- and eco-friendly leave-on hand sanitizer to prevent the spread of respiratory viruses. An oil-in-water emulsion containing C. recutita oily extract (5.0%), C. recutita glycolic extract (0.2%) and C. sinensis glycolic extract (5.0%) showed virucidal activity against HAdV-2 (respiratory virus) and two surrogate viruses of SARS-CoV-2 (HSV-1 and MVH-3), showing great potential to prevent the spread of respiratory viruses. These natural extracts combined are also promising to combat a broad spectrum of other viruses, in the form of antiseptic mouthwashes or throat sprays, surface disinfectants, and veterinary products, among others. Complementally, the developed hand sanitizer demonstrated efficacy against bacteria and fungus.

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Acknowledgements

The authors are thankful to LAMEB—Multipurpose Laboratory for Biological Studies, Federal University of Santa Catarina, Brazil—for the assistance provided during the virucidal assays and Analysis Center of the Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Brazil—for the support in rotational rheological analysis.

Funding

The authors would like to thank the funding agencies CAPES/MEC (Ministry of Education) and CNPq/MCTI (Ministry of Science, Technology, and Innovation) for the scholarships awarded. The authors also thank the companies Heide, Colormix, Inolex, Razzini & Partners, Dinaco, and Sarfam for donating supplies employed in this study.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Marina Gomes, Isabella Dai Prá Zuchi, Izabella Thaís da Silva & Bianca Ramos Pezzini

  2. Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Catielen Paula Pavi, Gislaine Fongaro & Izabella Thaís da Silva

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  1. Marina Gomes
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Contributions

Marina Gomes: Conceptualization, Methodology, Investigation, Data curation, Formal analysis, Validation, Writing—original draft. Isabella Dai Prá Zuchi: Investigation. Catielen Paula Pavi: Investigation. Gislaine Fongaro: Conceptualization, Resources, Supervision, Methodology, Investigation, Formal analysis, Writing—review & editing. Izabella Thaís da Silva: Conceptualization, Supervision, Methodology, Formal analysis, Writing—review & editing. Bianca Ramos Pezzini: Conceptualization, Resources, Supervision, Methodology, Formal analysis, Writing—review & editing.

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Correspondence to Bianca Ramos Pezzini.

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Gomes, M., Zuchi, I.D.P., Pavi, C.P. et al. Skin- and Eco-Friendly Hand Sanitizer: A Novel Composition of Natural Extracts to Prevent the Spread of Respiratory Viruses. AAPS PharmSciTech 25, 98 (2024). https://doi.org/10.1208/s12249-024-02808-8

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