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Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium

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A Correction to this article was published on 30 November 2023

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Abstract

The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon® SR (KSR) in the presence of different excipients such as Microcrystalline cellulose (MCC), Monohydrous lactose (MH Lactose), Poly (vinyl acetate) (PVA100), and a water-soluble drug Diclofenac sodium (DNa) to prepare once daily formulation. Tablets were prepared using direct compression and were compressed into flat-faced tablets using hydraulic press at various pressures. The combination of MCC and KSR in the tablets showed reduced porosity, and almost constant low Py values as KSR levels increased; also, KSR-DNa tablets had higher percentage porosity and crushing strength values than KSR-MH Lactose tablets. The crushing strengths of KSR-MCC tablets were larger than those of KSR-DNa tablets. Ternary mixture tablets comprised of KSR-MCC-DNa showed decreased porosities and low Py values as the percentage of KSR increased especially at high compression pressures but had higher crushing strengths compared to KSR-DNa or MCC-DNa binary tablets. KSR-MH Lactose-DNa ternary tablets experienced lower porosities and crushing strengths compared to KSR-MCC-DNa tablets. Quaternary tablets of KSR-PVA100-MCC-DNa showed lower porosity and Py values than quaternary tablets obtained using similar proportion of MH Lactose instead of MCC. In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.

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Funding

This study received funding (grant 184/2021) from the Jordan University of Science and Technology (JUST).

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  1. Faculty of Pharmacy, Department of Pharmaceutical Technology, Jordan University of Science and Technology, B. O. Box 3030, Irbid, 22110, Jordan

    Wasfy M. Obeidat & Ishraq K. Lahlouh

  2. Faculty of Pharmacy, Jerash University, Jerash, 26150, Jordan

    Shadi F. Gharaibeh

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Wasfy M. Obeidat: conceptualization, study design, data collection, analysis, and interpretation; writing the paper. Ishraq K. Lahlouh helped in performing most of the experimental work and plotting the produced data. Shadi F. Gharaibeh provided assistance with the original manuscript’s writing, data analysis, and interpretation.

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Obeidat, W.M., Lahlouh, I.K. & Gharaibeh, S.F. Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium. AAPS PharmSciTech 24, 225 (2023). https://doi.org/10.1208/s12249-023-02685-7

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