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Supersaturable Solid Self-microemulsifying Delivery Systems of Astaxanthin via Spray Drying: Effects of Polymers and Solid Carriers

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Abstract

This study aimed to develop the solid astaxanthin-encapsulated self-microemulsifying delivery system (S-AST SMEDS) spray-dried particles and investigate the effect of materials in formulations on product characteristics. The optimized liquid AST SMEDS incorporated with a polymeric precipitation inhibitor (PI) was solidified with a solid carrier by spray drying. Physicochemical properties of S-AST SMEDS spray-dried powders including morphology, particle size and distribution, flowability, solid-state characters, moisture content, yield, loading capacity of AST, and reconstitution properties were examined. Polymeric PIs seemed to have an impact on particles’ size, surface smoothness, and flowability while solid carriers had an effect on the particles’ moisture content and droplet size of microemulsions obtained after reconstitution. The amount of AST encapsulated in S-SMEDS powder was influenced by both polymer and solid carriers. Dissolution and short-term stability of S-AST SMEDS were also studied. Our developed spray-dried solid SMEDS particles helped enhance AST dissolution rate.

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Data Availability

Data generated and analyzed in this research are included in this paper. Appropriate citations and references are provided for any data derived from previous publications.

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Acknowledgements

One of the authors (W.T.A.) would like to thank Chulalongkorn University’s Scholarship Program for ASEAN Countries for providing financial aid during her doctoral studies. The authors would also like to thank the Pharmaceutical Research Instrument Center at the Faculty of Pharmaceutical Sciences and the Scientific and Technological Research Equipment Centre (STREC) at Chulalongkorn University for providing research instruments.

Funding

This research was supported by the Grant for Development of New Faculty Staff from the Ratchadaphiseksomphot Endowment Fund at Chulalongkorn University, Thailand (Grant ID: DNS 62_008_33_001_1) and was also supported by the Graduate School Thesis Grant, Chulalongkorn University, Thailand (Grant ID: GCUGR1225643034D No. 034).

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Authors and Affiliations

  1. Graduate Program of Pharmaceutical Sciences and Technology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand

    Wai Thet Aung

  2. Pharmaceutical Product Development and Technology Transfer (PDTT) Unit, Chulalongkorn University Drug and Health Products Innovation Promotion Center (CUDHIP), Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand

    Peerawas Kopongpanich

  3. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Wang Mai, Pathum Wan, Bangkok, 10330, Thailand

    Peerawas Kopongpanich & Veerakiet Boonkanokwong

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Contributions

W.T.A.: conceptualization, methodology, experimentation, data curation, visualization, validation, resources, writing—original draft. P.K.: visualization, validation, writing—review and editing. V.B.: conceptualization, methodology, data curation, visualization, formal analysis, validation, resources, writing—review and editing, supervision, project administration, funding acquisition.

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Correspondence to Veerakiet Boonkanokwong.

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Aung, W.T., Kopongpanich, P. & Boonkanokwong, V. Supersaturable Solid Self-microemulsifying Delivery Systems of Astaxanthin via Spray Drying: Effects of Polymers and Solid Carriers. AAPS PharmSciTech 24, 218 (2023). https://doi.org/10.1208/s12249-023-02671-z

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