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The Use of Nanoneedles in Drug Delivery: an Overview of Recent Trends and Applications

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Abstract

Nanoneedles (NN) are growing rapidly as a means of navigating biological membranes and delivering therapeutics intracellularly. Nanoneedle arrays (NNA) are among the most potential resources to achieve therapeutic effects by administration of drugs through the skin. Although this is based on well-established approaches, its implementations are rapidly developing as an important pharmaceutical and biological research phenomenon. This study intends to provide a broad overview of current NNA research, with an emphasis on existing approaches, applications, and types of compounds released by these systems. A nanoneedle-based delivery device with great spatial and temporal accuracy, minimal interference, and low toxicity could transfer biomolecules into living organisms. Due to its vast potential, NN has been widely used as a capable transportation system of many therapeutic active substances, from cancer therapy, vaccine delivery, cosmetics, and bio-sensing nanocarrier drugs to genes. The use of nanoneedles for drug delivery offers new opportunities for the rapid, targeted, and exact administration of biomolecules into cell membranes for high-resolution research of biological systems, and it can treat a wide range of biological challenges. As a result, the literature has analyzed existing patents to emphasize the status of NNA in biological applications.

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Funding

The authors received financial support from the Deanship of Scientific Research at King Khalid University, Saudi Arabia, through the Large Program (grant number RGP-2/264/44).

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia

    Mohamed Rahamathulla & Ali H. Alamri

  2. Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, 570015, Karnataka, India

    Santhosh Murugesan, D. V. Gowda, Riyaz Ali M. Osmani, Sathish Ramamoorthy & Balamuralidhara Veeranna

  3. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia

    Mohammed Muqtader Ahmed

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  1. Mohamed Rahamathulla
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Contributions

Conceptualization, BV, and MR; methodology, SM, DVG, MAS, AA, and RAMO; software, SM, KSA, and SA; validation, MMA, SA, and AA; formal analysis, SM, DVG, and KC; investigation, MMA and SR; resources, SM, SR and MR; data curation, SR, RAMO, BV, and MMA; writing—original draft preparation, SM; writing—review and editing, BV, DVG, MR, and AA; visualization, SM, KSA; supervision, RAMO, MR, BV; project administration, BV, KSA, and MR; funding acquisition, MR. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Riyaz Ali M. Osmani or Balamuralidhara Veeranna.

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Rahamathulla, M., Murugesan, S., Gowda, D.V. et al. The Use of Nanoneedles in Drug Delivery: an Overview of Recent Trends and Applications. AAPS PharmSciTech 24, 216 (2023). https://doi.org/10.1208/s12249-023-02661-1

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