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Therapeutic Potential of Nanocarrier-Mediated Delivery of Phytoconstituents for Wound Healing: Their Current Status and Future Perspective

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A Correction to this article was published on 05 October 2023

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Abstract

The treatment of wounds is a serious problem all over the world and imposes a huge financial burden on each and every nation. For a long time, researchers have explored wound dressing that speeds up wound healing. Traditional wound dressing does not respond effectively to the wound-healing process as expected. Therapeutic active derived from plant extracts and extracted bioactive components have been employed in various regions of the globe since ancient times for the purpose of illness, prevention, and therapy. About 200 years ago, most medical treatments were based on herbal remedies. Especially in the West, the usage of herbal treatments began to wane in the 1960s as a result of the rise of allopathic medicine. In recent years, however, there has been a resurgence of interest in and demand for herbal medicines for a number of reasons, including claims about their efficacy, shifting consumer preferences toward natural medicines, high costs and negative side effects of modern medicines, and advancements in herbal medicines brought about by scientific research and technological innovation. The exploration of medicinal plants and their typical uses could potentially result in advanced pharmaceuticals that exhibit reduced adverse effects. This review aims to present an overview of the utilization of nanocarriers in plant-based therapeutics, including its current status, recent advancements, challenges, and future prospects. The objective is to equip researchers with a comprehensive understanding of the historical background, current state, and potential future developments in this emerging field. In light of this, the advantages of nanocarriers based delivery of natural wound healing treatments have been discussed, with a focus on nanofibers, nanoparticles, nano-emulsion, and nanogels.

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Acknowledgements

The authors would like to thank Maharaja Ranjit Singh Punjab Technical University (MRSPTU) in Bathinda, India, for providing the research facilities. The authors would like to thank the Indian Council of Medical Research New Delhi, India, and the Faculty of Pharmacy, Kuala Lumpur, Malaysia for their contributions to the completion of this study.

Funding

Research grant (5/8–4/5/Env/2020-NCD-II Dated 22/12/2021) Under Indian Council of Medical Research (ICMR), New Delhi, India.

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  1. Mohit Kumar, Puja Keshwania have equal contribution.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India

    Mohit Kumar & Amit Bhatia

  2. Department of Microbiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, 133207, India

    Puja Keshwania

  3. Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, 201313, India

    Shruti Chopra

  4. Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia

    Syed Mahmood

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  1. Mohit Kumar
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  4. Syed Mahmood
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Contributions

Mohit Kumar: writing—original draft preparation, collecting information, methodology; Syed Mahmood: collecting information, revising draft; Shruti Chopra: collecting information, revising draft; Amit Bhatia: revising draft, conceptualization, finalizing the manuscript; Puja Keshwania: revising and finalizing the manuscript.

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Correspondence to Amit Bhatia.

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Kumar, M., Keshwania, P., Chopra, S. et al. Therapeutic Potential of Nanocarrier-Mediated Delivery of Phytoconstituents for Wound Healing: Their Current Status and Future Perspective. AAPS PharmSciTech 24, 155 (2023). https://doi.org/10.1208/s12249-023-02616-6

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