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Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment

  • Research Article
  • Active and Passive Permeation Enhancement Strategies for Transdermal Delivery of Bioactive Compounds
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Abstract

In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A specific area of skin was treated with 4 strokes of a dermaplane device. Interindividual variability was assessed by having multiple users operate the device for the study. Dermaplaned skin was histologically evaluated and characterized for resistance drop and the depletion of the stratum corneum (SC). The effect of dermaplaning on drug permeation was investigated via in vitro permeation studies. Histology studies depicted the removal of SC and some parts of viable epidermis by dermaplaning. A significant drop in electrical resistance post skin dermaplaning was observed for all treatment groups, signifying the depletion of barrier properties of SC (p < 0.05). Consequently, significant drug flux and permeation were observed over 24 h for the model drugs across dermaplaned skin. However, varied absorption profile was observed in vitro for both drugs across dermaplaned skin. Dermaplaning displayed a better suitability for significantly enhancing the permeation of the hydrophilic drug, baclofen. Evidence of variation in results post dermaplaning was observed amidst multiple users as well (p < 0.05).

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Data Availability

Authors confirm that all data supporting claims and conclusions in this article are available within the manuscript and we are willing to provide raw data files on request.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA

    Akeemat O. Tijani, Dorcas Frempong, Jagroop Kaur, Sophia Sergent, Kara Shaw, Rebecca Lessaint, Maryam Al Shawi, Gabrielle Verana & Ashana Puri

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  1. Akeemat O. Tijani
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  2. Dorcas Frempong
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  3. Jagroop Kaur
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  4. Sophia Sergent
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  5. Kara Shaw
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  6. Rebecca Lessaint
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  7. Maryam Al Shawi
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  8. Gabrielle Verana
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  9. Ashana Puri
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Contributions

Akeemat Tijani: acquisition, analysis, and interpretation of data, drafting and revising manuscript. Dorcas Frempong: acquisition, analysis, and interpretation of data. Jagroop Kaur: acquisition and analysis of data. Sophia Sergent: acquisition and analysis of data. Kara Shaw: acquisition and analysis of data. Rebecca Lessaint: acquisition and analysis of data. Maryam Al Shawi: acquisition and analysis of data. Gabrielle Verana: acquisition and analysis of data. Ashana Puri: supervision, acquisition, analysis of data, manuscript revision.

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Correspondence to Ashana Puri.

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Communicated by Jayachandra Babu Ramapuram and Ashana Puri.

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Tijani, A.O., Frempong, D., Kaur, J. et al. Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment. AAPS PharmSciTech 24, 54 (2023). https://doi.org/10.1208/s12249-023-02505-y

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