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Proliposome-Based Nanostrategies: Challenges and Development as Drug Delivery Systems

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Abstract

Many attempts have been made to the refinement of liposomal stability. In 1986, Payne et al. developed the approach of proliposomes to derelict the physicochemical instability confronted in some liposome suspensions, i.e., fusion, aggregation, hydrolysis, and oxidation. This review attempts to cover different aspects of proliposomes along with their types and preparation methods. The review is also focused on the scope of proliposomes as a nano-based drug delivery system and subsequent applications. An attempt has been made to cover all the facets of proliposomes, from their composition to clinical trials. The extensive scientific data from proliposomes provide substantial shreds of evidence for its huge delivery potential.

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Funding

The authors acknowledge the support offered by the Department of Pharmacy, Central University of Rajasthan, India.

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  1. Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, India, 305817

    Mangilal Choudhary, Nishtha Chaurawal & Kaisar Raza

  2. Department of Pharmaceutics, College of Pharmacy, University of Hafr Al-Batin, Al Jamiah, 39524, Hafr Al Batin, Saudi Arabia

    Md. Abul Barkat

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  1. Mangilal Choudhary
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  2. Nishtha Chaurawal
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Mangilal Chaudhary: data collection, writing; Nishtha Chaurawal: data validation, drafting and proof reading; Md. Abul Barkat: revision of manuscript; Kaisar Raza: conceptualization, supervision, organization, and drafting.

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Correspondence to Kaisar Raza.

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Choudhary, M., Chaurawal, N., Barkat, M.A. et al. Proliposome-Based Nanostrategies: Challenges and Development as Drug Delivery Systems. AAPS PharmSciTech 23, 293 (2022). https://doi.org/10.1208/s12249-022-02443-1

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