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Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts

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Abstract

To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared. Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5. Therefore, HPMC-VLV is a more effective excipient for reducing CFE sticking during spray drying. The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min. Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2–30 μm. Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity. HPMC covered the droplet surface and reduced surface tension, achieving an anti-sticking effect. In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE. The spray-drying process parameters were nonlinearly related to the dry product yield.

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Funding

This work was sponsored by the National Natural Science Foundation of China (81503263, 82003958) and the Natural Science Foundation of Shanghai (20ZR1458400, 18ZR1439800).

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Authors and Affiliations

  1. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Innovation Research Institute of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Hong Cheng, Lijie Zhao & Youjie Wang

  2. Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China

    Chenghao Lu

  3. Shanghai Pudong Institute for Food and Drug Control, Shanghai, 201203, People’s Republic of China

    Gangfeng Xu

  4. Science and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Min Lu

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  1. Hong Cheng
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  2. Chenghao Lu
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  4. Lijie Zhao
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  5. Min Lu
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Contributions

Methodology and technical support, Hong Cheng, Chenghao Lu, Gangfeng Xu, and Min Lu; writing the draft manuscript, Hong Cheng and Chenghao Lu; reviewing and editing the manuscript, Hong Cheng and Youjie Wang; funding acquisition, Youjie Wang and Lijie Zhao.

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Correspondence to Youjie Wang.

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Cheng, H., Lu, C., Xu, G. et al. Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts. AAPS PharmSciTech 23, 58 (2022). https://doi.org/10.1208/s12249-022-02215-x

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  • DOI: https://doi.org/10.1208/s12249-022-02215-x

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