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Table IV Experimental Molar Fraction Solubility (Cm,T) Values as the Mean of Three Experiments (± Standard Deviation) Measured for Acetylsalicylic Acid in Ethanol + Water Solvent Mixtures at 25 and 37°C in the Presence of Salicylic Acid (as its Degradation Product)

From: Solubility Study of Acetylsalicylic Acid in Ethanol + Water Mixtures: Measurement, Mathematical Modeling, and Stability Discussion

f1a 25C 37°C
Acetylsalicylic acid
0.00 2.46 (±0.06) × 10–2 3.08 (±0.00) × 10–2
0.10 3.47 (±0.11) × 10–2 5.22 (±0.01) × 10–2
0.20 5.92 (±0.25) × 10–2 1.01 (±0.00) × 10–1
0.30 1.28 (±0.00) × 10–1 2.04 (±0.04) × 10–1
0.40 2.71 (±0.05) × 10–1 4.09 (±0.03) × 10–1
0.50 4.31 (±0.02) × 10–1 6.71 (±0.08) × 10–1
0.60 5.46 (±0.14) × 10–1 8.16 (±0.92) × 10–1
0.70 6.82 (±0.03) × 10–1 9.95 (±0.16) × 10–1
0.80 7.77 (±0.02) × 10–1 1.06 (±0.19)
0.90 8.68 (±0.52) × 10–1 1.13 (±0.08)
1.00 8.26 (±0.23) × 10–1 9.88 (±0.02) × 10–1
Salicylic acidb
0.00 7.26 (±0.12) × 10–4 [1.37 × 10–2] 3.20 (±0.13) × 10–3
0.10 8.78 (±0.63) × 10–4 [1.73 × 10–2] 4.47 (±0.25) × 10–3
0.20 1.04 (±0.09) × 10–3 [3.24 × 10–2] 7.78 (±0.60) × 10–3
0.30 1.95 (±0.00) × 10–3 [8.09 × 10–2] 1.84 (±0.00) × 10–2
0.40 1.86 (±0.00) × 10–3 [2.10 × 10–1] 3.24 (±0.00) × 10–2
0.50 2.98 (±0.00) × 10–3 [4.81 × 10–1] 4.31 (±0.00) × 10–2
0.60 3.16 (±0.00) × 10–3 [9.62 × 10–1] 4.52 (±0.00) × 10–2
0.70 3.67 (±0.05) × 10–3 [1.38] 5.33 (±0.00) × 10–2
0.80 3.28 (±0.73) × 10–3 [1.84] 5.52 (±0.44) × 10–2
0.90 3.73 (±0.00) × 10–3 [2.21] 4.94 (±0.01) × 10–2
1.00 3.38 (±0.52) × 10–3 [2.11] 5.24 (±0.01) × 10–2
  1. af1 is volume fraction of ethanol in the ethanol and water mixtures in the absence of acetylsalicylic acid
  2. bMolar concentration produced from hydrolysis of acetylsalicylic acid. Data in bracket are related to saturated concentration for salicylic acid in ethanol + water mixtures and taken from a reference (56)