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Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and ReadyMix for paediatric dosage forms

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Abstract

The taste of drug substances plays a key role in the development of paediatric formulations with suitable organoleptic properties. The aim of the study was to evaluate the taste masking effectiveness of Smartseal 30D and ReadyMix on a range of bitter drug substances such as diphenhydramine HCl (DPD), ibuprofen lysine (IBU-LS), and phenylephrine HCl (PPH) for the development of paediatric dosage forms. The drugs were microencapsulated in the polymer carriers at 10–20% loadings using spray-drying processing. Spray drying of drug formulations was optimized in terms of percent yield and encapsulation efficiency followed by physicochemical characterization in order to identify the drugs’ physical state in the polymer microparticles. The in vivo taste masking efficiency was evaluated using human test panel and showed noticeable reduction of drug’s bitterness at all loadings in comparison to the bulk substances.

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Authors and Affiliations

  1. Faculty of Engineering and Science, University of Greenwich, Medway Campus, ME4 4TB, Chatham Maritime, Kent, UK

    Leona Chidinma Muoka, Md Sadeque Hossain Mithu, Uttom Nandi & Dennis Douroumis

  2. Cubi-Tech Extrusion Limited, Unit 3, Sextant park, Neptune Close, Rochester, Kent, ME2 4LU, UK

    Steven A. Ross

  3. CIPER Centre for Innovation and Process Engineering Research, Kent, ME4 4TB, UK

    Steven A. Ross, Md Sadeque Hossain Mithu, Uttom Nandi & Dennis Douroumis

Authors
  1. Leona Chidinma Muoka
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  2. Steven A. Ross
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  3. Md Sadeque Hossain Mithu
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  4. Uttom Nandi
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  5. Dennis Douroumis
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Correspondence to Dennis Douroumis.

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Muoka, L.C., Ross, S.A., Mithu, M.S.H. et al. Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and ReadyMix for paediatric dosage forms. AAPS PharmSciTech 22, 141 (2021). https://doi.org/10.1208/s12249-021-02002-0

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  • DOI: https://doi.org/10.1208/s12249-021-02002-0

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