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A Novel Drug Delivery System: the Encapsulation of Naringenin in Metal-Organic Frameworks into Liposomes

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Abstract

Poorly water-soluble naringenin (NAR) was selected as a model drug and loaded into the porous MOFs for the construction of NAR@ZIF-8 inclusion complex. By film dispersion method, NAR@ZIF-8 was further encapsulated into liposomes to fabricate a novel drug delivery system. Liposomes and a novel drug delivery system were established. Subsequently, the lipid-drug ratio, phospholipid-cholesterol ratio, and hydration temperature were investigated using the Box-Behnken design based the single factor experiment. The prepared liposomes system showed spherical or quasi-spherical shape, uniform particle size distribution, and complete structure. More specifically, the average particle size was 113.2 ± 1.4 nm, and zeta potential was − 7.536 ± 0.264 mV. Moreover, the drug release behaviors of NAR, NAR@ZIF-8, and NAR@ZIF-8 liposomes were explored in vitro. Compared with free NAR and NAR@ZIF-8 which exhibited a burst drug release, NAR@ZIF-8 liposomes showed a more sustained release behavior with 79.86% drug release in 72 h. In vitro cytotoxicity experiments showed that, compared with free NAR and NAR@ZIF-8, NAR@ZIF-8 liposomes exhibited higher inhibition efficiency on lung adenocarcinoma A549 cells and gastric cancer SGC-7901 cells in a concentration-dependent manner.

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Funding

We acknowledge financial support by the NSFC (51902079), Key projects of Anhui Provincial Department of Education (KJ2017A626), and Anhui Province College Excellent Young Talents Fund (gxyq2020076).

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Author notes

  1. Zhangjie Wang and Lingli Liu contributed equally to this work.

Authors and Affiliations

  1. College of Pharmacy, Anhui Xinhua University, No.555, Wangjiang West Road, Hefei, 230088, People’s Republic of China

    Zhangjie Wang, Ziping Liu & Lingli Shi

  2. College of Energy, Materials and Engineering, Hefei University, Hefei, 230601, China

    Lingli Liu

  3. College of Hefei Technology, Hefei, 230012, China

    Wei Yin

  4. Chemistry College, Sichuan University, Chengdu, 610064, China

    Maoxing Tang

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  1. Zhangjie Wang
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  2. Lingli Liu
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Correspondence to Zhangjie Wang.

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Wang, Z., Liu, L., Yin, W. et al. A Novel Drug Delivery System: the Encapsulation of Naringenin in Metal-Organic Frameworks into Liposomes. AAPS PharmSciTech 22, 61 (2021). https://doi.org/10.1208/s12249-021-01927-w

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