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The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating

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Abstract

Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited. Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs. In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X). Their physical properties were characterized comprehensively. The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly. The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time. The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs. These findings are beneficial to the development of herbal core-shell CPs for DC.

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Abbreviations

Ad:

Adhesiveness

AR:

Angle of repose

AUC:

Area under curve

AUTCC:

The area under tensile strength versus compaction force curve

CF:

Compaction force

ChP:

Chinese Pharmacopeia

CI:

Carr’s index

Co:

Cohesiveness

CP:

Composite particle

CP X-H:

Composite particles containing HPMC

CP X-P:

Composite particles containing PVP

CR:

Compaction ratio

d(0.5):

Median particle size

E SP :

Net energy per unit of quality

F :

Breaking force

f :

Equilibrium hygroscopic moisture content

Ha:

Hardness

HPMC/H:

Hydroxypropyl methylcellulose

HR:

Hausner ratio

k :

Moisture absorption constant

MC:

Moisture content

PL:

Percentage of net energy except friction energy

PM:

Physical mixture

PVP/P:

Polyvinylpyrrolidone

P y :

Yield pressure

ρ b :

Bulk density

ρ t :

Tapped density

ρ true :

True density

Re:

Resilience

R 2 :

Square of the correlation coefficient

Sp:

Springiness

Span:

Particle size distribution

TS:

Tensile strength

Un:

Uniformity

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Funding

This work was funded by the National Natural Science Foundation of China (81973490), China; Natural Science Foundation of Shanghai (18ZR1439800, 18ZR1436600), China; China Postdoctoral Science Foundation (2019 M662278), China; Construction of Collaborative Innovation Center of Shanghai (2020-Sci&Tec-01-01-30), China; Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ190688), China; Three-year Action Plan for the Development of Traditional Chinese Medicine of Shanghai Municipal Health Planning Commission (ZY(2018-2020)-CCCX-2001-03), China; and Xinglin Young Scholar Program of Shanghai University of Traditional Chinese Medicine, China (A1-U17205010416); Postdoctoral Science Foundation of Jiangxi Province, China (2019KY42); Program of Jiangxi University of Traditional Chinese Medicine, China (2004/538200010402).

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Authors and Affiliations

  1. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Zhe Li, Lan Shen & Xiao Lin

  2. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China

    Zhe Li

  3. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Fei Wu & Yi Feng

  4. Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    YanLong Hong

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  1. Zhe Li
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  2. Fei Wu
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  3. YanLong Hong
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  4. Lan Shen
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Correspondence to YanLong Hong or Xiao Lin.

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Li, Z., Wu, F., Hong, Y. et al. The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating. AAPS PharmSciTech 21, 201 (2020). https://doi.org/10.1208/s12249-020-01739-4

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