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Pharmacokinetic Study of Ferulic Acid Following Transdermal or Intragastric Administration in Rats

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Abstract

Ferulic acid is contained in some Chinese herbal medicines such as Ligusticum chuanxiong or Angelica sinensis. Studies have focused on the treatment of inflammatory diseases and pain using ferulic acid. However, little is known about its pharmacokinetics after transdermal administration. The present research investigated the pharmacokinetic behavior of ferulic acid in rat plasma and skin microdialysate after ferulic acid transdermal or intragastric administration. Samples collected at predetermined time points were determined by a simple and sensitive HPLC-UV method. The pharmacokinetic parameters were estimated using non-compartmental analysis with DAS 2.0 software. The values of AUC0-t and Cmax after intragastric administration (20 mg/kg) in plasma were 281.47 ± 46.76 min mg/L and 12.20 ± 2.46 mg/L, respectively. After emulsion transdermal administration (117 mg/kg, 35 mg/4 cm2), the values of AUC0-t and Cmax in plasma and skin microdialysate were 953.90 ± 175.30 min mg/L, 7630.47 ± 1410.33 min mg/L, 3.00 ± 0.61 mg/L, and 19.08 ± 4.39 mg/L, respectively. Here, we show a promising delivery system for ferulic acid that could replace traditional administration, and a better understanding of the transdermal pharmacokinetics of ferulic acid, which may be helpful for further clinical and laboratory studies.

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Funding

The paper is supported by Key Laboratory of Neuropsychiatric Drug Reserch of Zhejiang Province (2019E10021).

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Author notes

  1. Na Yan and Zhan Tang contributed equally to this work.

Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University of Technology, 8 Chaowang Road, Hangzhou, 310014, People’s Republic of China

    Na Yan & Yuqi Xu

  2. Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, 182 Tianmu Road, Hangzhou, 310013, People’s Republic of China

    Na Yan, Zhan Tang, Yuqi Xu, Xiumin Li & Qiao Wang

Authors
  1. Na Yan
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  2. Zhan Tang
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  3. Yuqi Xu
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Correspondence to Qiao Wang.

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Yan, N., Tang, Z., Xu, Y. et al. Pharmacokinetic Study of Ferulic Acid Following Transdermal or Intragastric Administration in Rats. AAPS PharmSciTech 21, 169 (2020). https://doi.org/10.1208/s12249-020-01709-w

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