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A Rundown Through Various Methods Used in the Formulation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS)

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Abstract

The most common route of the drug administration is oral route despite the fact that most drugs have low oral aqueous solubility and bioavailability especially for BCS class II and class IV drugs. Many methods have been developed in recent years to overcome the poor solubility and oral bioavailability which includes self-emulsifying drug delivery systems (SEDDS) as one of the approaches. Not only for hydrophobic drugs, but also for hydrophilic compounds with low permeability, bioavailability can be enhanced by self nanoemulsifying drug delivery systems. Recently, a lot of focus and attention has been put in the conversion of liquid SEDDS (L-SEDDS) to solid SEDDS (S-SEDDS) to overcome the limitations of liquid formulations related to their physical and chemical stability, portability, accurate dosing, and limited choices of dosage forms. This article aims to review the formulation components used in SEDDS, various approaches used in the conversion of L-SEDDS to S-SEDDS, their applications, merits, and demerits.

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References

  1. Sharma S, Bajaj H, Bhardwaj P, Sharma AD, Singh R. Development and characterization of self emulsifying drug delivery system of a poorly water soluble drug using natural oil. Acta Pol Pharm Drug Res. 2012;69(4):713–7.

    CAS  Google Scholar 

  2. Chowdary KA, Babu VP, Baratam SR. Formulation and in vitro characterisation of self emulsifying drug delivery system of Diclofenac. IJRASET. 2017;5(II):663–72.

    Article  Google Scholar 

  3. Silva LAD, Almeida SL, Alonso ECP, Priscila BR, Martins FT, Freitas LAP, et al. Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion. Int J Pharm. 2018;541(1-2):1–10. https://doi.org/10.1016/j.ijpharm.2018.02.020.

    Article  CAS  PubMed  Google Scholar 

  4. Cheng G, Hu R, Ye L, Wang B, Gui Y, Gao S, et al. Preparation and in vitro / in vivo evaluation of puerarin solid self-microemulsifying drug delivery system by spherical crystallization technique. AAPS PharmSciTech. 2016;17(6):1336–46. https://doi.org/10.1208/s12249-015-0469-8.

    Article  CAS  PubMed  Google Scholar 

  5. Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm. 2001;212:233–46.

    Article  CAS  Google Scholar 

  6. Madagul JK, Parakh DR, Kumar RS, Abhang RR. Formulation and evaluation of solid self micro-emulsifying drug delivery system (S-SMEDDS) of chlorthalidone by spray drying technology. Dry Technol. 2016. https://doi.org/10.1080/07373937.2016.1201833.

    Article  Google Scholar 

  7. Chintalapudi R, Murthy TEGK, Lakshmi KR, Manohar GG. Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine. Int J Pharm Investig. 2015;5(4):205–13.

    Article  CAS  Google Scholar 

  8. Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharm. 2013. https://doi.org/10.1155/2013/848043.

    Article  Google Scholar 

  9. Gurav NP, Dandagi PM, Gadad AP. Solubility enhancement of satranidazole using self emulsified drug delivery systems. Indian J Pharm Educ Res. 2016;50(3). https://doi.org/10.5530/ijper.50.2.2050(3).

  10. Müllertz A, Ogbonna A, Ren S. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. J Pharm Pharmacol. 2010;62:1622–36. https://doi.org/10.1111/j.2042-7158.2010.01107.x.

    Article  CAS  PubMed  Google Scholar 

  11. Dokania S, Joshi AK. Self-microemulsifying drug delivery system (SMEDDS)—challenges and road ahead. Drug Deliv. 2015;22(6):675–90. https://doi.org/10.3109/10717544.2014.896058.

    Article  CAS  PubMed  Google Scholar 

  12. Pouton CW. Lipid formulations for oral administration of the drugs: non-emulsifying, self-emulsifying and “self-microemulsifying” drug delivery systems. Eur J Pharm Sci. 2000;11(Suppl. 2):S93–8.

    Article  CAS  Google Scholar 

  13. Pouton CW. Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci. 2006;29:278–87. https://doi.org/10.1016/j.ejps.2006.04.016.

    Article  CAS  PubMed  Google Scholar 

  14. Pouton CW, Porter CJH. Formulation of lipid-based delivery systems for oral administration : materials , methods and strategies. Adv Drug Deliv Rev. 2008;60:625–37.

    Article  CAS  Google Scholar 

  15. Myers RA, Stella VJ. Systemic bioavailability of penclomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats. Int J Pharm. 1992;78(1–3):217–26.

    Article  CAS  Google Scholar 

  16. Carrigan PJ, Bates TR. Biopharmaceutics of the drugs administered in lipid-containing dosage forms I: GI absorption of griseofulvin from an oil-in-water emulsion in the rat. J Pharm Sci. 1973;62(9):1476–9.

    Article  CAS  Google Scholar 

  17. Rahman MA, Hussain A, Hussain MS, Mirza MA, Iqbal Z. Role of excipients in successful development of self-emulsifying/ microemulsifying drug delivery system (SEDDS/SMEDDS). Drug Dev Ind Pharm. 2013;39(1):1–19. https://doi.org/10.3109/03639045.2012.660949.

    Article  CAS  PubMed  Google Scholar 

  18. Truong DH, Tran TH, Ramasamy T, Choi JY, Lee HH, Moon C, et al. Development of solid self-emulsifying formulation for improving the oral bioavailability of erlotinib. AAPS PharmSciTech. 2016;17(2):466–73. https://doi.org/10.1208/s12249-015-0370-5.

    Article  CAS  PubMed  Google Scholar 

  19. Porter CJH, Pouton CW, Cuine JF, Charman WN. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev. 2008;60:673–91.

    Article  CAS  Google Scholar 

  20. Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res. 2004;21(2):201–30.

    Article  CAS  Google Scholar 

  21. Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173–82.

    Article  Google Scholar 

  22. Khan BA, Bakhsh S, Khan H, Mahmood T, Rasul A. Basics of self micro emulsifying drug delivery system. J Pharm Alternat Med. 2012;1(M):13–20.

    Google Scholar 

  23. Small DM. A classification of biologic lipids based upon their interaction in aqueous systems. J Am Oil Chem Soc. 1968;45:108–19.

    Article  CAS  Google Scholar 

  24. Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Nano emulsion components screening and selection: a technical note. AAPS PharmSciTech. 2009;10(1):69–76. https://doi.org/10.1208/s12249-008-9178-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Yetukuri K, Satisha P, Srinivasan S, Thakur RS, Uma Shankar MS. Solid-self emulsifying drug delivery system : formulation techniques and dosage forms. 2011;10(3):87–93.

  26. Saurabh SS, Issarani R, Nagori BP. Formulation and evaluation of self-emulsifying drug delivery system of etoricoxib. Asian J Pharm Clin Res. 2017;10(7):367–72.

    Article  CAS  Google Scholar 

  27. Sinha VR, Ghai D. Formulation design and development of self-nanoemulsifying drug delivery systems containing a hydrophobic selective β1-adrenoreceptor blocker. Int J Nanosci Nanotechnol. 2010;6(3):154–67.

    Google Scholar 

  28. Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today. 2008;13(13/14):606–12.

    Article  CAS  Google Scholar 

  29. Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo evaluation. Drug Deliv. 2015;22(4):552–61. https://doi.org/10.3109/10717544.2013.878003.

    Article  CAS  PubMed  Google Scholar 

  30. Zvonar A. Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs. Acta Pharma. 2013;63:427–45. https://doi.org/10.2478/acph-2013-0040.

    Article  CAS  Google Scholar 

  31. Soliman KAB, Ibrahim HK, Ghorab MM. Formulation of risperidone as self-nanoemulsifying drug delivery system in form of effervescent tablets. J Dispers Sci Technol. 2012;33(8):1127–33. https://doi.org/10.1080/01932691.2011.599235.

    Article  CAS  Google Scholar 

  32. Nokhodchi A, Maghsoodi M. Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique. AAPS PharmSciTech. 2008;9(1):54–9. https://doi.org/10.1208/s12249-007-9019-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Sun C, Gui Y, Hu R, Chen J, Wang B, Guo Y, et al. Preparation and pharmacokinetics evaluation of solid self-microemulsifying drug delivery system ( S-SMEDDS ) of osthole. AAPS PharmSciTech. 2018;19(5):2301–10. https://doi.org/10.1208/s12249-018-1067-3.

    Article  CAS  PubMed  Google Scholar 

  34. Maghsoodi M, Nokhodchi A. Agglomeration of celecoxib by quasi emulsion solvent diffusion method: effect of stabilizer. Adv Pharm Bull. 2016;6(4):607–16. https://doi.org/10.15171/apb.2016.075.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Dobry DE, Settell DM, Baumann JM, Ray RJ, Graham LJ, Beyerinck RA. A model-based methodology for spray-drying process development. J Pharm Innov. 2009;4(3):133–42. https://doi.org/10.1007/s12247-009-9064-4.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Hong MJ, Jee JP, et al. Enhanced oral bioavailability of dexibuprofen by a novel solid Self-emulsifying drug delivery system (SEDDS). Eur J Pharm Biopharm. 2009;72(3):539–45. https://doi.org/10.1016/j.ejpb.2009.03.001.

    Article  CAS  PubMed  Google Scholar 

  37. Rajesh SY, Singh SK, Pandey NK, Sharma P, Bawa P, Kumar B, et al. Impact of various solid carriers and spray drying on pre/post compression properties of solid SNEDDS loaded with glimepiride: in vitro-ex vivo evaluation and cytotoxicity assessment. Drug Dev Ind Pharm. 2018. https://doi.org/10.1080/03639045.2018.1431656.

    Article  CAS  Google Scholar 

  38. Kim DW, Kang JH, Oh DH, Yong CS, Choi HG. Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier. J Microencapsul. 2012;29(4):323–30. https://doi.org/10.3109/02652048.2011.651497.

    Article  CAS  PubMed  Google Scholar 

  39. Chen Y, Chen C, Zheng J, Chen Z, Shi Q, Liu H. Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability. Biol Pharm Bull. 2011;34(2):278–86.

    Article  CAS  Google Scholar 

  40. Bushra R, Ahmed A, Shahadat M. Mechanism of adsorption on nanomaterials. Nanomater Chromatogr. 2017;2: 90-111 p. https://doi.org/10.1016/B978-0-12-812792-6/00004-2.

  41. Cirri M, Roghi A, Valleri M, Mura P. Development and characterization of fast- dissolving tablet formulations of glyburide based on solid self-microemulsifying systems. Eur J Pharm Biopharm. 2016. https://doi.org/10.1016/j.ejpb.2016.04.008.

    Article  CAS  Google Scholar 

  42. Patel H, Patel P, Patel M, Mehta D, Misan C. Development and characterization of liquid and solid self-microemulsifying drug delivery system of Tacrolimus. Asian J Pharm. 2012;43:385–94. https://doi.org/10.1007/s40005-013-0083-2.

    Article  CAS  Google Scholar 

  43. Javed M, Mallikarjun C, Gan W. Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets : a study in diet induced hyperlipidemic. Asian J Pharm Sci. 2015;10(1):40–56. https://doi.org/10.1016/j.ajps.2014.08.003.

    Article  Google Scholar 

  44. Gumaste SG, Freire BOS, Serajuddin ATM. Development of solid SEDDS, VI: effect of precoating of Neusilin® US2 with PVP on drug release from adsorbed self-emulsifying lipid-based formulations. Eur J Pharm Sci. 2017. https://doi.org/10.1016/j.ejps.2017.02.022.

    Article  CAS  Google Scholar 

  45. Tan DK, Maniruzzaman M, Nokhodchi A. Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery. Pharmaceutics. 2018;10:203. https://doi.org/10.3390/pharmaceutics10040203.

    Article  CAS  PubMed Central  Google Scholar 

  46. Tiwari RV, Patil H, Repka MA. Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century. Expert Opin Drug Deliv. 2016;13(3):451–64. https://doi.org/10.1517/17425247.2016.1126246.

    Article  CAS  PubMed  Google Scholar 

  47. Takabe H, Warnken ZN, Zhang Y, Davis DA, Smyth HDC, Kuhn JG, et al. A repurposed drug for brain cancer: Enhanced atovaquone amorphous solid dispersion by combining a spontaneously emulsifying component with a polymer carrier. Pharmaceutics. 2018;10:60. https://doi.org/10.3390/pharmaceutics10020060.

    Article  CAS  PubMed Central  Google Scholar 

  48. Bhandari V, Avachat A. Formulation and characterization of self emulsifing pellets of carvedilol. Braz J Pharm Sci. 2015;51(3):663–72. https://doi.org/10.1590/S1984-82502015000300018.

    Article  Google Scholar 

  49. Zhiyuan W. Solid self-emulsifying nitrendipine pellets: preparation and in vitro/in vivo evaluation. Int J Pharm. 383:1–6. https://doi.org/10.1016/j.ijpharm.2010;2009.08.014.

  50. Abbaspour M, Jalayer N, Makhmalzadeh BS. Development and evaluation of a solid self-nanoemulsifying drug delivery system for loratadin by extrusion-spheronization. Adv Pharm Bull. 2014;4(2):113–9. https://doi.org/10.5681/apb.2014.018.

    Article  CAS  PubMed  Google Scholar 

  51. Abdalla A, Klein S, Mäder K. A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci. 2008;35(5):457–64.

    Article  CAS  Google Scholar 

  52. Madan J, Sudarshan B, Kadam V, Kamal D. Formulation and development of self-microemulsifying drug delivery system of pioglitazone hydrochloride. Asian J Pharm. 2014; Available from: http://www.asiapharmaceutics.info/text.asp 2014/8/1/27/134097.

  53. Kanaujia P, Ng WK, Tan RBH. Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate. J Microencapsul. 2014. https://doi.org/10.3109/02652048.2013.843601.

    Article  Google Scholar 

  54. Mcconville C, Friend D. Development and characterisation of a self-microemulsifying drug delivery systems ( SMEDDSs ) for the vaginal administration of the antiretroviral UC-781. Eur J Pharm Biopharm. 2013;83:322–9. https://doi.org/10.1016/j.ejpb.2012.10.007.

    Article  CAS  PubMed  Google Scholar 

  55. Tsinontides SC, Rajniak P, Pham D, Hunke WA, Placek J, Reynolds SD. Freeze drying—principles and practice for successful scale-up to manufacturing. Int J Pharm. 2004;280:1–16.

    Article  CAS  Google Scholar 

  56. Gaidhani KA, Harwalkar M, Bhambere D. Lyophilization / freeze drying—a review. World J Pharm Res. 2015;4(8):516–43.

    CAS  Google Scholar 

  57. Yang X, Li F, Guo Y, Zhang X, Pan W, Zhao Q, et al. Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam. Drug Deliv. 2014. https://doi.org/10.3109/10717544.2014.885615.

    Article  Google Scholar 

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  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Sharel Rency D. Almeida & Vamshi Krishna Tippavajhala

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Almeida, S.R.D., Tippavajhala, V.K. A Rundown Through Various Methods Used in the Formulation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS). AAPS PharmSciTech 20, 323 (2019). https://doi.org/10.1208/s12249-019-1550-5

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