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Crystal Transformation of β-CD-MOF Facilitates Loading of Dimercaptosuccinic Acid

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Abstract

The β-cyclodextrin-metal-organic framework (β-CD-MOF), a potential drug delivery carrier, presents a densely packed laminated crystal structure (CCDC number 1041782) that prevents drug from entering inside the molecular voids in most CD units. In this paper, it was demonstrated that dimercaptosuccinic acid (DMSA), an instable small molecule chemical drug, was successfully loaded in β-CD-MOF with a high molar ratio of 1:1.35 (β-CD-MOF:DMSA) determined by high-performance liquid chromatography. The drug loading mechanism of β-CD-MOF/DMSA was supported by a series of experimental characterizations and molecular simulations. The morphology observations revealed that crystalline particles of β-CD-MOF transformed to reticular microstructure after drug loading evidenced by powder X-ray diffraction (PXRD), scanning electron microscope (SEM), synchrotron radiation Fourier transform infrared spectroscopy (SR-FTIR), and etc. It is of interest to note that the stability of DMSA was well improved by β-CD-MOF, but decreased by γ-CD-MOF, indicating different protective capacities between the two types of CD-MOFs. Thus, it is hypothesized that the transformation from laminated molecular arrangement of β-CD-MOF to reticular microstructure leads to an enhanced drug-loading capability for delivery of specific drugs.

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Acknowledgments

We thank the staffs from BL01B beamline of National Center for Protein Science Shanghai (NCPSS) at Shanghai Synchrotron Radiation Facility for their assistance in SR-FTIR data collection.

Funding

The authors were financially supported by the project funded by the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” (2018ZX09721002-009), Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA12050307).

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Author notes

  1. Yuehuai Xiong and Li Wu contributed equally to this work.

Authors and Affiliations

  1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China

    Yuehuai Xiong, Wenting Wu, Yan Tang, Ting Xiong, Yong Zhou, Weifeng Zhu & Jiwen Zhang

  2. Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China

    Yuehuai Xiong, Li Wu, Tao Guo, Caifen Wang, Yan Tang, Ting Xiong, Yong Zhou & Jiwen Zhang

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  1. Yuehuai Xiong
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  2. Li Wu
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Correspondence to Weifeng Zhu or Jiwen Zhang.

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Xiong, Y., Wu, L., Guo, T. et al. Crystal Transformation of β-CD-MOF Facilitates Loading of Dimercaptosuccinic Acid. AAPS PharmSciTech 20, 224 (2019). https://doi.org/10.1208/s12249-019-1422-z

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