Interactions Between Biological Products and Product Packaging and Potential Approaches to Overcome Them

Abstract

Biological products such as protein-based biopharmaceuticals are playing an important role in the healthcare and pharmaceutical industry. The interaction between biological products and packaging materials has become the focus of many studies since it can reduce the effectiveness of biological products. These interactions are heavily influenced by the surface properties and physicochemical nature of the therapeutic agents and the packaging materials. Therefore, it is critical to understand the interactions between packaging materials and biological products in order to design biocompatible packaging materials and develop approaches to minimize adverse interactions. We describe the interactions that occur when using several common packaging materials, including glass and polymer. We discuss the interaction between these materials and biological products such as blood, blood derivatives, recombinant proteins, monoclonal antibodies, and gene therapeutics. We also summarize approaches for overcoming these interactions. Understanding the interactions between biological materials and packaging materials is critical for the development of novel packaging materials that improve the safety of pharmaceutical products.

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Correspondence to S. N. Murthy.

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Wang, M., Li, Y., Srinivasan, P. et al. Interactions Between Biological Products and Product Packaging and Potential Approaches to Overcome Them. AAPS PharmSciTech 19, 3681–3686 (2018). https://doi.org/10.1208/s12249-018-1184-z

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Key Words

  • biological
  • interaction
  • packaging
  • stability
  • incompatibility