Mechanical Characterization and Dissolution of Chewing Gum Tablets (CGTs) Containing Co-compressed Health in Gum® and Curcumin/Cyclodextrin Inclusion Complex
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Curcumin chewing gums could be therapeutically beneficial if used by the head and neck cancer patients. High curcumin loading in chewing gums however is needed to achieve desired therapeutic effect. Preparing gums with high drug load is nonetheless challenging because of the negative impact of solids on their masticatory properties. The use of liquid flavors was found to partially solve this problem. The objectives of this study were to (1) determine the maximum amount of curcumin that can be loaded into co-compressed chewing gums made from Health in Gum® as the base and flavored with 1.5% peppermint oil, (2) determine if addition of sweeteners can improve the yield strength and compressibility of the gums when examined by a texture analyzer, (3) examine the effect of temperature over a storage period of one month on the physical stability of the chewing gums, and (4) study the impact of substituting curcumin with its inclusion complex with SBE-β-CD on drug release. It was found that when flavored, Health in Gum® could load up to 25% curcumin by weight without compromising its masticatory properties. When tested for drug release, SBE-β-CD was found to significantly increase the amount of curcumin dissolved within 30 min. Despite poor drug release from gums loaded with insoluble curcumin, the fragmentation of the gums during mastication by the Erweka tester is nonetheless expected to produce a suspension for absorption in the lower GIT. This study demonstrated how modulating gum composition and storage conditions can impact the mechanical properties of chewing gums with high solids content.
KEY WORDSchewing gum curcumin cyclodextrin textural analysis tablet
The government of Saudi Arabia and Hail University are acknowledged for providing fellowship support to T.A.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 6.C.-A. Nathan, Microsized curcumin compositions, in, Google Patents, 2016.Google Scholar
- 7.C.A. Nathan, J.D. Boudreaux, Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders, in, Google Patents, 2017.Google Scholar
- 8.C.A. Nathan, J.D. Boudreaux, Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders, in, Google Patents, 2018.Google Scholar
- 10.T. Al Hagbani, S. Nazzal, Development of postcompressional textural tests to evaluate the mechanical properties of medicated chewing gum tablets with high drug loadings. J Texture Stud, (2017).Google Scholar
- 15.M.R. Marques, R. Loebenberg, M. Almukainzi, Simulated biological fluids with possible application in dissolution testing.Google Scholar
- 17.D. Mazurek, J.T. DeWolf, F.P. Beer, E.R. Johnston, Statics and Mechanics of Materials, McGraw-Hill Education, 2016.Google Scholar
- 18.D. Hull, D.J. Bacon, Introduction to Dislocations, Elsevier Science, 2011.Google Scholar
- 19.Bourne MC. Food Texture and Viscosity: Concept and Measurement. New York: Academic Press, Inc.; 1982.Google Scholar