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Levobupivacaine Thermogel for Long-acting Analgesia

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Abstract

The adequate management of analgesia, by pharmacological methods or not, is a great challenge. Local anesthetics are used for pain relief, mainly by parenteral, intramuscular, catheter, and other routes of administration. The use of in situ forming systems becomes an alternative for the control of pain. The present research investigates development of thermogels containing poloxamer and levobupivacaine. All formulations were prepared by the cold method; the compatibilities of the excipients were evaluated by DSC, rheology and viscosities, transition temperature, syringeability, release kinetics, and permeation. The compatibility of the tested excipients with the drug was initially observed; all formulations had a viscosity increase at 37°C. Different delivery rates were observed in both the release and permeation studies. The developed systems maintained the in vitro release of the drug for a long period, likely decreasing side effects in vivo and avoiding the need for supplementary analgesia by other routes.

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Acknowledgements

The authors would like to thank Cristália Prod. Quim. Farm. LTDA for kindly providing Novapubi®, NUDFAC/Farmácia Escola Carlos Drummond de Andrade/UFPE, and Centro de Tecnologias Estratégicas do Nordeste (CETENE).

Funding

This study received a grant from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil)

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Authors and Affiliations

  1. Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil

    Ellison Neves de Lima, Ana Rosa Brissant de Andrade, Leila Bastos Leal & Davi Pereira de Santana

  2. Cidade Universitária, Recife, PE, 50740-520, Brazil

    Leila Bastos Leal

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  1. Ellison Neves de Lima
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  3. Leila Bastos Leal
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Correspondence to Leila Bastos Leal.

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These experiments on rats were approved by the Ethical Committee of the Federal University of Pernambuco (Registration no. 23076.007923/2017-61) and performed in automated Franz diffusion cells (Vision® Microette automated diffusion test system, Chatsworth, USA).

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de Lima, E.N., de Andrade, A.R.B., Leal, L.B. et al. Levobupivacaine Thermogel for Long-acting Analgesia. AAPS PharmSciTech 19, 2533–2542 (2018). https://doi.org/10.1208/s12249-018-1083-3

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