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Development of Microemulsions and Microemulgels for Enhancing Transdermal Delivery of Kaempferia parviflora Extract

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Abstract

The purpose of this research was to develop microemulsions (ME) and microemulgels (MG) for enhancing transdermal delivery of Kaempferia parviflora (KP) extract. The methoxyflavones were used as markers. Various formulations of ME and MG containing 10% w/v KP extract were prepared, and the in vitro skin permeation and deposition were investigated. The potential ME system containing oleic acid (5% w/v), Tween 20 (20% w/v), PG (40% w/v), and water (35% w/v) was successfully formulated. ME with 10% w/v limonene (ME-L10%) showed higher methoxyflavones flux than ME-L5%, ME-L1%, ME without limonene, and KP extract in water, respectively. ME-L10% was selected for adding a gelling agent to form microemulgels (MG-L10%). However, the high viscosity of the gel formulation might control the diffusion of the compound from gel layer into the skin. Therefore, the liquid formulation provided potential ME droplets to deliver KP extract through the skin. Limonene also plays an effective role on the skin permeation, in which the histological image of the skin treated with ME-L10% exhibited larger space of each flattened keratinocyte layer in the stratum corneum compared to the skin treated with KP extract in water. Moreover, ME-L10% showed good stability. Therefore, ME-L10% was a potential formulation for improving transdermal delivery of KP extract.

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Acknowledgements

The authors would like to acknowledge the Faculty of Pharmacy, Silpakorn University, the Thailand Research Funds (IRN58W0004), and the National Natural Science Foundation of China (NSFC 81561148012) for the financial supports and Bangkok Lab & Cosmetic Co., Ltd., for Kaempferia parviflora (KP) extract and standard methoxyflavones.

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Authors and Affiliations

  1. Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand

    Worranan Rangsimawong, Paisit Wattanasri, Prasopchai Tonglairoum, Prasert Akkaramongkolporn, Theerasak Rojanarata, Tanasait Ngawhirunpat & Praneet Opanasopit

  2. Bangkok Lab & Cosmetic Co., Ltd., Ratchaburi, Thailand

    Paisit Wattanasri

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  1. Worranan Rangsimawong
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  2. Paisit Wattanasri
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  3. Prasopchai Tonglairoum
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Correspondence to Praneet Opanasopit.

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Rangsimawong, W., Wattanasri, P., Tonglairoum, P. et al. Development of Microemulsions and Microemulgels for Enhancing Transdermal Delivery of Kaempferia parviflora Extract. AAPS PharmSciTech 19, 2058–2067 (2018). https://doi.org/10.1208/s12249-018-1003-6

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