AAPS PharmSciTech

, Volume 19, Issue 4, pp 1637–1646 | Cite as

Mucoadhesive Properties of Eudragit®RS100, Eudragit®S100, and Poly(ε-caprolactone) Nanocapsules: Influence of the Vehicle and the Mucosal Surface

  • Paula Dos Santos ChavesEmail author
  • Luiza Abrahão FrankEmail author
  • Alejandro Germán Frank
  • Adriana Raffin Pohlmann
  • Sílvia Stanisçuaski Guterres
  • Ruy Carlos Ruver Beck
Research Article


The use of polymers as mucoadhesive materials has been explored in several drug delivery systems. It is well known that the resulting mucoadhesiveness not only depends on the polymers by themselves, but also on the way they are delivered and on the application target. However, little attention has been given to the combined effect of such characteristics. Therefore, the objective of this study is to analyze the mucoadhesion resulting from combined effects of nanocapsules produced with polymers of different ionic properties, Eudragit®RS100, Eudragit®S100, or poly(ε-caprolactone), when they are incorporated into different vehicles (suspension, hydrogel, and powder) and applied on different mucosal surfaces (mucin, porcine vaginal, and buccal mucosa). Mucoadhesion was measured by a tensile stress tester. Our findings show that polymeric self-assembling as nanocapsules improved the mucoadhesion of the polymers. Eudragit®RS100 nanocapsules have the best performance, independently of the vehicle and surface used. Regarding the vehicle, hydrogels showed higher adhesion when compared to suspensions and powders. When considering different types of surfaces, mucin presented a similar pattern like the animal mucosa, but it overestimated the mucoadhesiveness of all formulations. In conclusion, this study demonstrated that the best strategy to achieve high mucoadhesive formulations is by incorporating Eudragit®RS100 nanocapsules in hydrogels. Moreover, mucin is a suitable substrate to compare and screen different formulations but not as a conclusive estimation of the mucoadhesion values that can be achieved. These results are summarized in a decision tree that can help to understand different strategies of combination of these factors and the expected outcomes.


polymeric nanocapsules mucoadhesion mucin disc porcine mucosa vehicle 



The authors thank the following Brazilian agencies: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) for financial support.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Paula Dos Santos Chaves
    • 1
    Email author
  • Luiza Abrahão Frank
    • 1
    Email author
  • Alejandro Germán Frank
    • 2
  • Adriana Raffin Pohlmann
    • 1
    • 3
  • Sílvia Stanisçuaski Guterres
    • 1
  • Ruy Carlos Ruver Beck
    • 1
  1. 1.Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de FarmáciaUniversidade Federal do Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  2. 2.Núcleo de Engenharia Organizacional (NEO), Departamento de Engenharia de Produção e TransportesUniversidade Federal do Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  3. 3.Departamento de Química Orgânica, Instituto de QuímicaUniversidade Federal do Rio Grande do Sul (UFRGS)Porto AlegreBrazil

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